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Sputum examination for the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Am Rev Respir Dis. 1986 Feb; 133(2):226-9.AR

Abstract

The diagnostic utility of sputum examination in patients with Pneumocystis carinii pneumonia secondary to the acquired immunodeficiency syndrome (AIDS) has so far not been determined. Sputum was induced in 43 patients with AIDS or suspected AIDS just prior to fiberoptic bronchoscopy, scheduled because of an unexplained pulmonary infiltrate on a chest radiograph. Pneumocystis carinii pneumonia was diagnosed by sputum examination and/or by a bronchoscopic procedure in 20 patients. Of these, sputum samples were positive for Pneumocystis organisms in 11 (55%) of 20 patients tested, bronchial washings were positive in 11 (79%) of 14 patients tested, brush biopsies were positive in 9 (53%) of 17 patients tested, and transbronchial lung biopsies were positive in 18 (90%) of 20 patients tested. The presence of P. carinii cysts in sputum did not correlate with the presence of alveolar macrophages in sputum nor with the volume of sputum. Sputum examination for P. carinii organisms, employed as a first diagnostic step in patients with AIDS with pulmonary infiltrates, may frequently obviate the need for bronchoscopy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3484921

Citation

Pitchenik, A E., et al. "Sputum Examination for the Diagnosis of Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome." The American Review of Respiratory Disease, vol. 133, no. 2, 1986, pp. 226-9.
Pitchenik AE, Ganjei P, Torres A, et al. Sputum examination for the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Am Rev Respir Dis. 1986;133(2):226-9.
Pitchenik, A. E., Ganjei, P., Torres, A., Evans, D. A., Rubin, E., & Baier, H. (1986). Sputum examination for the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. The American Review of Respiratory Disease, 133(2), 226-9.
Pitchenik AE, et al. Sputum Examination for the Diagnosis of Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome. Am Rev Respir Dis. 1986;133(2):226-9. PubMed PMID: 3484921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sputum examination for the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. AU - Pitchenik,A E, AU - Ganjei,P, AU - Torres,A, AU - Evans,D A, AU - Rubin,E, AU - Baier,H, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 226 EP - 9 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 133 IS - 2 N2 - The diagnostic utility of sputum examination in patients with Pneumocystis carinii pneumonia secondary to the acquired immunodeficiency syndrome (AIDS) has so far not been determined. Sputum was induced in 43 patients with AIDS or suspected AIDS just prior to fiberoptic bronchoscopy, scheduled because of an unexplained pulmonary infiltrate on a chest radiograph. Pneumocystis carinii pneumonia was diagnosed by sputum examination and/or by a bronchoscopic procedure in 20 patients. Of these, sputum samples were positive for Pneumocystis organisms in 11 (55%) of 20 patients tested, bronchial washings were positive in 11 (79%) of 14 patients tested, brush biopsies were positive in 9 (53%) of 17 patients tested, and transbronchial lung biopsies were positive in 18 (90%) of 20 patients tested. The presence of P. carinii cysts in sputum did not correlate with the presence of alveolar macrophages in sputum nor with the volume of sputum. Sputum examination for P. carinii organisms, employed as a first diagnostic step in patients with AIDS with pulmonary infiltrates, may frequently obviate the need for bronchoscopy. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/3484921/Sputum_examination_for_the_diagnosis_of_Pneumocystis_carinii_pneumonia_in_the_acquired_immunodeficiency_syndrome_ DB - PRIME DP - Unbound Medicine ER -