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Diagnosis of Pneumocystis carinii pneumonia. Roentgenographic-pathologic correlates based on fiberoptic bronchoscopy specimens from patients with the acquired immunodeficiency syndrome.
Chest. 1986 Apr; 89(4):522-6.Chest

Abstract

We analyzed the diagnosis of Pneumocystis carinii pneumonia by fiberoptic bronchoscopy in a large series of patients with the acquired immunodeficiency syndrome (AIDS). Transbronchial biopsy fragments, as opposed to endobronchial specimens, were found to have high diagnostic value. Their optimal number for diagnosis was determined by a simple statistical principle. It varied from a minimum of two in cases of severe pneumonia to a maximum of four when roentgenographic manifestations were altogether absent. The diagnostic yield of the transbronchial biopsy alone was 97 percent and that of "touch" preparations of the biopsies 88 percent; when both techniques were combined, the accuracy rose to 98 percent. By comparison, bronchial "washings" and "brushings" had a much lower yield, 59 percent and 57 percent, respectively. Because their diagnostic contribution was negligible, we conclude that the latter two procedures represent an unnecessary expense and waste of technical and professional effort.

Authors

Mones JM
No affiliation info available
Saldana MJ
No affiliation info available
Oldham SA
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultBiopsyBronchoscopyFiber Optic TechnologyHumansLungMaleMiddle AgedPneumonia, PneumocystisRadiographyTherapeutic Irrigation

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3485514

Citation

Mones, J M., et al. "Diagnosis of Pneumocystis Carinii Pneumonia. Roentgenographic-pathologic Correlates Based On Fiberoptic Bronchoscopy Specimens From Patients With the Acquired Immunodeficiency Syndrome." Chest, vol. 89, no. 4, 1986, pp. 522-6.
Mones JM, Saldana MJ, Oldham SA. Diagnosis of Pneumocystis carinii pneumonia. Roentgenographic-pathologic correlates based on fiberoptic bronchoscopy specimens from patients with the acquired immunodeficiency syndrome. Chest. 1986;89(4):522-6.
Mones, J. M., Saldana, M. J., & Oldham, S. A. (1986). Diagnosis of Pneumocystis carinii pneumonia. Roentgenographic-pathologic correlates based on fiberoptic bronchoscopy specimens from patients with the acquired immunodeficiency syndrome. Chest, 89(4), 522-6.
Mones JM, Saldana MJ, Oldham SA. Diagnosis of Pneumocystis Carinii Pneumonia. Roentgenographic-pathologic Correlates Based On Fiberoptic Bronchoscopy Specimens From Patients With the Acquired Immunodeficiency Syndrome. Chest. 1986;89(4):522-6. PubMed PMID: 3485514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of Pneumocystis carinii pneumonia. Roentgenographic-pathologic correlates based on fiberoptic bronchoscopy specimens from patients with the acquired immunodeficiency syndrome. AU - Mones,J M, AU - Saldana,M J, AU - Oldham,S A, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 522 EP - 6 JF - Chest JO - Chest VL - 89 IS - 4 N2 - We analyzed the diagnosis of Pneumocystis carinii pneumonia by fiberoptic bronchoscopy in a large series of patients with the acquired immunodeficiency syndrome (AIDS). Transbronchial biopsy fragments, as opposed to endobronchial specimens, were found to have high diagnostic value. Their optimal number for diagnosis was determined by a simple statistical principle. It varied from a minimum of two in cases of severe pneumonia to a maximum of four when roentgenographic manifestations were altogether absent. The diagnostic yield of the transbronchial biopsy alone was 97 percent and that of "touch" preparations of the biopsies 88 percent; when both techniques were combined, the accuracy rose to 98 percent. By comparison, bronchial "washings" and "brushings" had a much lower yield, 59 percent and 57 percent, respectively. Because their diagnostic contribution was negligible, we conclude that the latter two procedures represent an unnecessary expense and waste of technical and professional effort. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/3485514/Diagnosis_of_Pneumocystis_carinii_pneumonia__Roentgenographic_pathologic_correlates_based_on_fiberoptic_bronchoscopy_specimens_from_patients_with_the_acquired_immunodeficiency_syndrome_ DB - PRIME DP - Unbound Medicine ER -