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BCG vaccination strategies against tuberculosis: updates and perspectives.
Hum Vaccin Immunother. 2021 12 02; 17(12):5284-5295.HV

Abstract

Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB). However, BCG has variable efficacy and cannot completely prevent TB infection and transmission. Therefore, the worldwide prevalence of TB calls for urgent development of a more effective TB vaccine. In the absence of other approved vaccines, it is also necessary to improve the efficacy of BCG itself. Intravenous (IV) BCG administration and BCG revaccination strategies have recently shown promising results for clinical usage. Therefore, it is necessary for us to revisit the BCG vaccination strategies and summarize the current research updates related to BCG vaccination. This literature review provides an updated overview and perspectives of the immunization strategies against TB using BCG, which may inspire the following research on TB vaccine development.

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Authors+Show Affiliations

Qu M
College of Veterinary Medicine, China Agricultural University, Beijing, China. Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, China Agricultural University, Beijing, China.
Zhou X
College of Veterinary Medicine, China Agricultural University, Beijing, China. Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, China Agricultural University, Beijing, China.
Li H
College of Veterinary Medicine, China Agricultural University, Beijing, China. Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China.

MeSH

BCG VaccineHumansImmunization, SecondaryMycobacterium bovisMycobacterium tuberculosisTuberculosisTuberculosis VaccinesVaccination

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34856853

Citation

Qu, Mengjin, et al. "BCG Vaccination Strategies Against Tuberculosis: Updates and Perspectives." Human Vaccines & Immunotherapeutics, vol. 17, no. 12, 2021, pp. 5284-5295.
Qu M, Zhou X, Li H. BCG vaccination strategies against tuberculosis: updates and perspectives. Hum Vaccin Immunother. 2021;17(12):5284-5295.
Qu, M., Zhou, X., & Li, H. (2021). BCG vaccination strategies against tuberculosis: updates and perspectives. Human Vaccines & Immunotherapeutics, 17(12), 5284-5295. https://doi.org/10.1080/21645515.2021.2007711
Qu M, Zhou X, Li H. BCG Vaccination Strategies Against Tuberculosis: Updates and Perspectives. Hum Vaccin Immunother. 2021 12 2;17(12):5284-5295. PubMed PMID: 34856853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BCG vaccination strategies against tuberculosis: updates and perspectives. AU - Qu,Mengjin, AU - Zhou,Xiangmei, AU - Li,Hao, Y1 - 2021/12/02/ PY - 2021/12/4/pubmed PY - 2022/4/19/medline PY - 2021/12/3/entrez KW - BCG KW - BCG revaccination KW - tuberculosis KW - vaccine routes SP - 5284 EP - 5295 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 17 IS - 12 N2 - Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB). However, BCG has variable efficacy and cannot completely prevent TB infection and transmission. Therefore, the worldwide prevalence of TB calls for urgent development of a more effective TB vaccine. In the absence of other approved vaccines, it is also necessary to improve the efficacy of BCG itself. Intravenous (IV) BCG administration and BCG revaccination strategies have recently shown promising results for clinical usage. Therefore, it is necessary for us to revisit the BCG vaccination strategies and summarize the current research updates related to BCG vaccination. This literature review provides an updated overview and perspectives of the immunization strategies against TB using BCG, which may inspire the following research on TB vaccine development. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/34856853/BCG_vaccination_strategies_against_tuberculosis:_updates_and_perspectives_ DB - PRIME DP - Unbound Medicine ER -