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Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia.
Br J Haematol. 2022 06; 197(5):609-617.BJ

Abstract

The loss of red blood cell (RBC) deformability in sickle cell anaemia (SCA) is considered the primary factor responsible for episodes of acute pain and downstream progressive organ dysfunction. Oxygen gradient ektacytometry (Oxygenscan) is a recently commercialised functional assay that aims to describe the deformability of RBCs in SCA at differing oxygen tensions. So far, the Oxygenscan has been evaluated only by a small number of research groups and the validity and clinical value of Oxygenscan-derived biomarkers have not yet been fully established. In this study we examined RBC deformability measured with the Oxygenscan in 91 children with SCA at King's College Hospital in London. We found a significant correlation between Oxygenscan-derived biomarkers and well-recognised modifiers of disease severity in SCA: haemoglobin F and co-inherited α-thalassaemia. We failed, however, to find any independent predictive value of the Oxygenscan in the clinical outcome measure of pain, as well as other important parameters such as hydroxycarbamide treatment. Although the Oxygenscan remains an intriguing tool for basic research, our results question whether it provides any additional information in predicting the clinical course in children with SCA, beyond measuring known markers of disease severity.

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Authors+Show Affiliations

Nardo-Marino A
Department of Haematology, Centre for Haemoglobinopathies, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark. Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark. Department of Haematological Medicine, King's College Hospital, London, United Kingdom. School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom.
Petersen J
Department of Haematology, Centre for Haemoglobinopathies, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
Brewin JN
Department of Haematological Medicine, King's College Hospital, London, United Kingdom. School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom.
Birgens H
Department of Haematology, Centre for Haemoglobinopathies, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
Williams TN
KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. Department of Medicine, Imperial College London, London, United Kingdom.
Kurtzhals JAL
Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark. Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
Rees DC
Department of Haematological Medicine, King's College Hospital, London, United Kingdom. School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom.
Glenthøj A
Department of Haematology, Centre for Haemoglobinopathies, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

MeSH

Anemia, Sickle CellBiomarkersChildErythrocyte DeformabilityHumansOxygenPain

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34859420

Citation

Nardo-Marino, Amina, et al. "Oxygen Gradient Ektacytometry Does Not Predict Pain in Children With Sickle Cell Anaemia." British Journal of Haematology, vol. 197, no. 5, 2022, pp. 609-617.
Nardo-Marino A, Petersen J, Brewin JN, et al. Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia. Br J Haematol. 2022;197(5):609-617.
Nardo-Marino, A., Petersen, J., Brewin, J. N., Birgens, H., Williams, T. N., Kurtzhals, J. A. L., Rees, D. C., & Glenthøj, A. (2022). Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia. British Journal of Haematology, 197(5), 609-617. https://doi.org/10.1111/bjh.17975
Nardo-Marino A, et al. Oxygen Gradient Ektacytometry Does Not Predict Pain in Children With Sickle Cell Anaemia. Br J Haematol. 2022;197(5):609-617. PubMed PMID: 34859420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia. AU - Nardo-Marino,Amina, AU - Petersen,Jesper, AU - Brewin,John N, AU - Birgens,Henrik, AU - Williams,Thomas N, AU - Kurtzhals,Jørgen A L, AU - Rees,David C, AU - Glenthøj,Andreas, Y1 - 2021/12/03/ PY - 2021/08/22/received PY - 2021/11/15/accepted PY - 2021/12/4/pubmed PY - 2022/5/31/medline PY - 2021/12/3/entrez KW - clinical trials KW - hydroxycarbamide KW - red blood cell deformability KW - sickle cell anaemia KW - α-thalassaemia SP - 609 EP - 617 JF - British journal of haematology JO - Br J Haematol VL - 197 IS - 5 N2 - The loss of red blood cell (RBC) deformability in sickle cell anaemia (SCA) is considered the primary factor responsible for episodes of acute pain and downstream progressive organ dysfunction. Oxygen gradient ektacytometry (Oxygenscan) is a recently commercialised functional assay that aims to describe the deformability of RBCs in SCA at differing oxygen tensions. So far, the Oxygenscan has been evaluated only by a small number of research groups and the validity and clinical value of Oxygenscan-derived biomarkers have not yet been fully established. In this study we examined RBC deformability measured with the Oxygenscan in 91 children with SCA at King's College Hospital in London. We found a significant correlation between Oxygenscan-derived biomarkers and well-recognised modifiers of disease severity in SCA: haemoglobin F and co-inherited α-thalassaemia. We failed, however, to find any independent predictive value of the Oxygenscan in the clinical outcome measure of pain, as well as other important parameters such as hydroxycarbamide treatment. Although the Oxygenscan remains an intriguing tool for basic research, our results question whether it provides any additional information in predicting the clinical course in children with SCA, beyond measuring known markers of disease severity. SN - 1365-2141 UR - https://www.unboundmedicine.com/medline/citation/34859420/Oxygen_gradient_ektacytometry_does_not_predict_pain_in_children_with_sickle_cell_anaemia_ DB - PRIME DP - Unbound Medicine ER -