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Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer.
Biomed Pharmacother. 2022 Jan; 145:112343.BP

Abstract

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hang Z
Daxing Research Institute, University of Science and Technology Beijing, China; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China.
Lei T
Daxing Research Institute, University of Science and Technology Beijing, China; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China.
Zeng Z
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China.
Cai S
Daxing Research Institute, University of Science and Technology Beijing, China; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China.
Bi W
Daxing Research Institute, University of Science and Technology Beijing, China; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China.
Du H
Daxing Research Institute, University of Science and Technology Beijing, China; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China. Electronic address: hongwudu@ustb.edu.cn.

MeSH

Alzheimer DiseaseAnimalsFecal Microbiota TransplantationGastrointestinal MicrobiomeHumansNeoplasmsParkinson DiseaseRisk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34864312

Citation

Hang, Zhongci, et al. "Composition of Intestinal Flora Affects the Risk Relationship Between Alzheimer's disease/Parkinson's Disease and Cancer." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 145, 2022, p. 112343.
Hang Z, Lei T, Zeng Z, et al. Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer. Biomed Pharmacother. 2022;145:112343.
Hang, Z., Lei, T., Zeng, Z., Cai, S., Bi, W., & Du, H. (2022). Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 145, 112343. https://doi.org/10.1016/j.biopha.2021.112343
Hang Z, et al. Composition of Intestinal Flora Affects the Risk Relationship Between Alzheimer's disease/Parkinson's Disease and Cancer. Biomed Pharmacother. 2022;145:112343. PubMed PMID: 34864312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer. AU - Hang,Zhongci, AU - Lei,Tong, AU - Zeng,Zehua, AU - Cai,Shanglin, AU - Bi,Wangyu, AU - Du,Hongwu, Y1 - 2021/12/01/ PY - 2021/9/3/received PY - 2021/10/9/revised PY - 2021/10/13/accepted PY - 2021/12/6/pubmed PY - 2022/3/11/medline PY - 2021/12/5/entrez KW - Alzheimer's disease KW - Cancer KW - Fecal microbiota transplantation KW - Intestinal flora KW - Parkinson's disease SP - 112343 EP - 112343 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 145 N2 - An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/34864312/Composition_of_intestinal_flora_affects_the_risk_relationship_between_Alzheimer's_disease/Parkinson's_disease_and_cancer_ DB - PRIME DP - Unbound Medicine ER -