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Stabilization of androgen receptor by nonandrogenic steroids.
Biochem Int. 1986 May; 12(5):701-5.BI

Abstract

Binding of androgens including 5 alpha-dihydrotestosterone, testosterone and androstenedione stabilized the androgen receptor from rat submandibular gland with respect to its [3H]methyltrienolone binding activity. Nonandrogenic steroids, 0.5 microM of progesterone and estradiol-17 beta, or 5 microM of triamcinolone acetonide also satisfactorily stabilized the androgen receptor. These results suggest that the association of ligands, even if those ligands were not stereospecific for the androgen receptor, stabilizes the androgen receptor and prevents the loss of its binding capacity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3488063

Citation

Nemoto, T, et al. "Stabilization of Androgen Receptor By Nonandrogenic Steroids." Biochemistry International, vol. 12, no. 5, 1986, pp. 701-5.
Nemoto T, Ohara-Nemoto Y, Sato M, et al. Stabilization of androgen receptor by nonandrogenic steroids. Biochem Int. 1986;12(5):701-5.
Nemoto, T., Ohara-Nemoto, Y., Sato, M., & Ota, M. (1986). Stabilization of androgen receptor by nonandrogenic steroids. Biochemistry International, 12(5), 701-5.
Nemoto T, et al. Stabilization of Androgen Receptor By Nonandrogenic Steroids. Biochem Int. 1986;12(5):701-5. PubMed PMID: 3488063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stabilization of androgen receptor by nonandrogenic steroids. AU - Nemoto,T, AU - Ohara-Nemoto,Y, AU - Sato,M, AU - Ota,M, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 701 EP - 5 JF - Biochemistry international JO - Biochem. Int. VL - 12 IS - 5 N2 - Binding of androgens including 5 alpha-dihydrotestosterone, testosterone and androstenedione stabilized the androgen receptor from rat submandibular gland with respect to its [3H]methyltrienolone binding activity. Nonandrogenic steroids, 0.5 microM of progesterone and estradiol-17 beta, or 5 microM of triamcinolone acetonide also satisfactorily stabilized the androgen receptor. These results suggest that the association of ligands, even if those ligands were not stereospecific for the androgen receptor, stabilizes the androgen receptor and prevents the loss of its binding capacity. SN - 0158-5231 UR - https://www.unboundmedicine.com/medline/citation/3488063/Stabilization_of_androgen_receptor_by_nonandrogenic_steroids_ DB - PRIME DP - Unbound Medicine ER -