TY - JOUR T1 - Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines. AU - Zhang,Yandi, AU - Banga Ndzouboukou,Jo-Lewis, AU - Gan,Mengze, AU - Lin,Xiaosong, AU - Fan,Xionglin, Y1 - 2021/11/22/ PY - 2021/09/06/received PY - 2021/10/29/accepted PY - 2021/12/9/entrez PY - 2021/12/10/pubmed PY - 2021/12/17/medline KW - COVID-19 KW - SARS-CoV-2 variants KW - epidemiology KW - immune evasive KW - vaccine efficacy SP - 771242 EP - 771242 JF - Frontiers in immunology JO - Front Immunol VL - 12 N2 - Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/34880867/Immune_Evasive_Effects_of_SARS_CoV_2_Variants_to_COVID_19_Emergency_Used_Vaccines_ DB - PRIME DP - Unbound Medicine ER -