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A soft Pickering emulsifier made from chitosan and peptides endows stimuli-responsiveness, bioactivity and biocompatibility to emulsion.
Carbohydr Polym. 2022 Feb 01; 277:118768.CP

Abstract

Polymeric Pickering emulsifiers may bring new insights to emulsion theory and practice due to their soft characters. Herein, a group of soft Pickering emulsifiers, chitosan-casein hydrophobic peptides nanoparticles (CS-CHP NPs) were prepared with a non-covalent anti-solvent procedure. The CS-CHP NPs provided the contact angles of 37.2°-87.4°, stabilizing O/W or W/O emulsions with enhanced thermal stability, endowing the emulsion with pH and CO2/N2 responsiveness. The emulsifying behavior and mechanism presented by CS-CHP NPs were different from that of ordinary hard Pickering emulsifiers, where the appropriate contact angle was 37.2° instead of 87.4° for stabilizing O/W emulsions. Moreover, the nanoparticles possess antioxidant, antibacterial activities and excellent biocompatibility. DPPH and ABTS scavenging activity of the CS-CHP NPs were >220% of that of CS NPs. The last, the emulsion provided high-efficient encapsulation of curcumin, making the soft Pickering emulsifiers a group candidate for drug delivery in food, cosmetics and pharmaceutical industry.

Authors+Show Affiliations

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: ymxia@jiangnan.edu.cn.School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: xueyihu@jiangnan.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34893215

Citation

Meng, Xinyu, et al. "A Soft Pickering Emulsifier Made From Chitosan and Peptides Endows Stimuli-responsiveness, Bioactivity and Biocompatibility to Emulsion." Carbohydrate Polymers, vol. 277, 2022, p. 118768.
Meng X, Liu H, Dong X, et al. A soft Pickering emulsifier made from chitosan and peptides endows stimuli-responsiveness, bioactivity and biocompatibility to emulsion. Carbohydr Polym. 2022;277:118768.
Meng, X., Liu, H., Dong, X., Wang, Q., Xia, Y., & Hu, X. (2022). A soft Pickering emulsifier made from chitosan and peptides endows stimuli-responsiveness, bioactivity and biocompatibility to emulsion. Carbohydrate Polymers, 277, 118768. https://doi.org/10.1016/j.carbpol.2021.118768
Meng X, et al. A Soft Pickering Emulsifier Made From Chitosan and Peptides Endows Stimuli-responsiveness, Bioactivity and Biocompatibility to Emulsion. Carbohydr Polym. 2022 Feb 1;277:118768. PubMed PMID: 34893215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A soft Pickering emulsifier made from chitosan and peptides endows stimuli-responsiveness, bioactivity and biocompatibility to emulsion. AU - Meng,Xinyu, AU - Liu,Huan, AU - Dong,Xinyu, AU - Wang,Qiqi, AU - Xia,Yongmei, AU - Hu,Xueyi, Y1 - 2021/10/18/ PY - 2021/06/23/received PY - 2021/10/04/revised PY - 2021/10/05/accepted PY - 2021/12/11/entrez PY - 2021/12/12/pubmed PY - 2022/3/16/medline KW - CO(2)/N(2) responsive KW - Chitosan KW - Curcumin KW - Hydrophobic peptide KW - Pickering emulsion KW - pH responsive SP - 118768 EP - 118768 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 277 N2 - Polymeric Pickering emulsifiers may bring new insights to emulsion theory and practice due to their soft characters. Herein, a group of soft Pickering emulsifiers, chitosan-casein hydrophobic peptides nanoparticles (CS-CHP NPs) were prepared with a non-covalent anti-solvent procedure. The CS-CHP NPs provided the contact angles of 37.2°-87.4°, stabilizing O/W or W/O emulsions with enhanced thermal stability, endowing the emulsion with pH and CO2/N2 responsiveness. The emulsifying behavior and mechanism presented by CS-CHP NPs were different from that of ordinary hard Pickering emulsifiers, where the appropriate contact angle was 37.2° instead of 87.4° for stabilizing O/W emulsions. Moreover, the nanoparticles possess antioxidant, antibacterial activities and excellent biocompatibility. DPPH and ABTS scavenging activity of the CS-CHP NPs were >220% of that of CS NPs. The last, the emulsion provided high-efficient encapsulation of curcumin, making the soft Pickering emulsifiers a group candidate for drug delivery in food, cosmetics and pharmaceutical industry. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/34893215/A_soft_Pickering_emulsifier_made_from_chitosan_and_peptides_endows_stimuli_responsiveness_bioactivity_and_biocompatibility_to_emulsion_ DB - PRIME DP - Unbound Medicine ER -