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Pharmacologic properties of serotonergic agents and antidepressant drugs.
J Clin Psychiatry 1987; 48 Suppl:5-11JC

Abstract

The ways in which pharmacologic intervention is possible in the synthesis, storage, release, inactivation, and actions of serotonin as a brain neurotransmitter are outlined, and the effects on serotonergic neuron function of the drugs used in the treatment of depression are discussed. Antidepressant drugs that inhibit monoamine oxidase increase brain concentrations of serotonin as well as other monoamines. Some tricyclic antidepressant drugs inhibit serotonin uptake along with norepinephrine uptake. There is some evidence that serotonin precursors and serotonin-releasing drugs can have antidepressant efficacy. Recently, selective inhibitors of serotonin uptake have been shown to be effective in the treatment of depression. Selective drugs for modulating serotonergic function will facilitate understanding of the role of serotonin and of specific subtypes of serotonin receptors in depression.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3493240

Citation

Fuller, R W.. "Pharmacologic Properties of Serotonergic Agents and Antidepressant Drugs." The Journal of Clinical Psychiatry, vol. 48 Suppl, 1987, pp. 5-11.
Fuller RW. Pharmacologic properties of serotonergic agents and antidepressant drugs. J Clin Psychiatry. 1987;48 Suppl:5-11.
Fuller, R. W. (1987). Pharmacologic properties of serotonergic agents and antidepressant drugs. The Journal of Clinical Psychiatry, 48 Suppl, pp. 5-11.
Fuller RW. Pharmacologic Properties of Serotonergic Agents and Antidepressant Drugs. J Clin Psychiatry. 1987;48 Suppl:5-11. PubMed PMID: 3493240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacologic properties of serotonergic agents and antidepressant drugs. A1 - Fuller,R W, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 5 EP - 11 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 48 Suppl N2 - The ways in which pharmacologic intervention is possible in the synthesis, storage, release, inactivation, and actions of serotonin as a brain neurotransmitter are outlined, and the effects on serotonergic neuron function of the drugs used in the treatment of depression are discussed. Antidepressant drugs that inhibit monoamine oxidase increase brain concentrations of serotonin as well as other monoamines. Some tricyclic antidepressant drugs inhibit serotonin uptake along with norepinephrine uptake. There is some evidence that serotonin precursors and serotonin-releasing drugs can have antidepressant efficacy. Recently, selective inhibitors of serotonin uptake have been shown to be effective in the treatment of depression. Selective drugs for modulating serotonergic function will facilitate understanding of the role of serotonin and of specific subtypes of serotonin receptors in depression. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/3493240/Pharmacologic_properties_of_serotonergic_agents_and_antidepressant_drugs_ L2 - https://medlineplus.gov/antidepressants.html DB - PRIME DP - Unbound Medicine ER -