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The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study.
Br J Nutr. 2022 12 14; 128(11):2219-2229.BJ

Abstract

Very few data are available regarding the association of adherence to the Mediterranean Diet (MeDi) with Subjective Cognitive Decline (SCD) evolution over time. A cohort of 939 cognitively normal individuals reporting self-experienced, persistent cognitive decline not attributed to neurological, psychiatric or medical disorders from the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD study) was followed-up for a mean period of 3·10 years. We defined our SCD score as the number of reported SCD domains (memory, language, visuoperceptual and executive), ranging from 0 to 4. Dietary intake at baseline was assessed through a food frequency questionnaire; adherence to the MeDi pattern was evaluated through the Mediterranean Diet Score (MDS) that ranged from 0 to 55, with higher values indicating greater adherence to the MeDi. The mean SCD score in our cohort increased by 0·20 cognitive domains during follow-up. After adjustment for multiple potential confounders, we showed that an MDS higher by 10 points was associated with a 7% reduction in the progression of SCD within one year. In terms of food groups, every additional vegetable serving consumption per day was associated with a 2·2% reduction in SCD progression per year. Our results provide support to the notion that MeDi may have a protective role against the whole continuum of cognitive decline, starting at the first subjective complaints. This finding may strengthen the role of the MeDi as a population-wide, cost-effective preventive strategy targeting the modifiable risk factors for cognitive decline.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Vlachos GS
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Yannakoulia M
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Anastasiou CA
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Kosmidis MH
Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dardiotis E
School of Medicine, University of Thessaly, Larissa, Greece.
Hadjigeorgiou G
School of Medicine, University of Thessaly, Larissa, Greece. Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Charisis S
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Sakka P
Athens Association of Alzheimer's Disease and Related Disorders, Maroussi, Greece.
Stefanis L
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Scarmeas N
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, USA.

MeSH

HumansAgedDiet, MediterraneanGreeceProspective StudiesCognitive DysfunctionAging

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34937581

Citation

Vlachos, George S., et al. "The Role of Mediterranean Diet in the Course of Subjective Cognitive Decline in the Elderly Population of Greece: Results From a Prospective Cohort Study." The British Journal of Nutrition, vol. 128, no. 11, 2022, pp. 2219-2229.
Vlachos GS, Yannakoulia M, Anastasiou CA, et al. The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study. Br J Nutr. 2022;128(11):2219-2229.
Vlachos, G. S., Yannakoulia, M., Anastasiou, C. A., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G., Charisis, S., Sakka, P., Stefanis, L., & Scarmeas, N. (2022). The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study. The British Journal of Nutrition, 128(11), 2219-2229. https://doi.org/10.1017/S0007114521005109
Vlachos GS, et al. The Role of Mediterranean Diet in the Course of Subjective Cognitive Decline in the Elderly Population of Greece: Results From a Prospective Cohort Study. Br J Nutr. 2022 12 14;128(11):2219-2229. PubMed PMID: 34937581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study. AU - Vlachos,George S, AU - Yannakoulia,Mary, AU - Anastasiou,Costas A, AU - Kosmidis,Mary H, AU - Dardiotis,Efthimios, AU - Hadjigeorgiou,Georgios, AU - Charisis,Sokratis, AU - Sakka,Paraskevi, AU - Stefanis,Leonidas, AU - Scarmeas,Nikolaos, Y1 - 2021/12/23/ PY - 2021/12/24/pubmed PY - 2022/12/22/medline PY - 2021/12/23/entrez KW - Dementia KW - Greece KW - Mediterranean diet KW - Nutrition KW - Subjective cognitive decline SP - 2219 EP - 2229 JF - The British journal of nutrition JO - Br J Nutr VL - 128 IS - 11 N2 - Very few data are available regarding the association of adherence to the Mediterranean Diet (MeDi) with Subjective Cognitive Decline (SCD) evolution over time. A cohort of 939 cognitively normal individuals reporting self-experienced, persistent cognitive decline not attributed to neurological, psychiatric or medical disorders from the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD study) was followed-up for a mean period of 3·10 years. We defined our SCD score as the number of reported SCD domains (memory, language, visuoperceptual and executive), ranging from 0 to 4. Dietary intake at baseline was assessed through a food frequency questionnaire; adherence to the MeDi pattern was evaluated through the Mediterranean Diet Score (MDS) that ranged from 0 to 55, with higher values indicating greater adherence to the MeDi. The mean SCD score in our cohort increased by 0·20 cognitive domains during follow-up. After adjustment for multiple potential confounders, we showed that an MDS higher by 10 points was associated with a 7% reduction in the progression of SCD within one year. In terms of food groups, every additional vegetable serving consumption per day was associated with a 2·2% reduction in SCD progression per year. Our results provide support to the notion that MeDi may have a protective role against the whole continuum of cognitive decline, starting at the first subjective complaints. This finding may strengthen the role of the MeDi as a population-wide, cost-effective preventive strategy targeting the modifiable risk factors for cognitive decline. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/34937581/The_role_of_Mediterranean_diet_in_the_course_of_subjective_cognitive_decline_in_the_elderly_population_of_Greece:_results_from_a_prospective_cohort_study_ DB - PRIME DP - Unbound Medicine ER -