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Research advances on surface plasmon resonance biosensors.
Nanoscale. 2022 Jan 20; 14(3):564-591.N

Abstract

The surface plasmon resonance (SPR) phenomenon is of wide interest due to its sensitivity to changes in surface refractive index for the label-free, highly sensitive and rapid detection of biomarkers. This paper reviews research progress on SPR biosensors modified with different substrate structures and surface materials, surface plasmon resonance imaging (SPRI), and SPR-enhanced electrochemiluminescent (ECL) biosensors for applications in biosensing in the last five years. This paper focuses on the research on the application of the SPR phenomenon in the field of bio-detection, reviews the sensing characteristics of SPR biosensors with substrate structures of prisms, gratings, and optical fibers, and summarizes and analyzes the sensitivity and interference resistance of SPR sensors with surface modification of different materials (high-refractive index dielectric films, metallic micro- and nanostructures, and surface antifouling materials). Considering that imaging is an important tool for biomedical detection, this paper reviews the research progress on SPRI technology in the field of biomedical detection. In addition, this paper also reviews the research progress on SPR-enhanced ECL biosensors in the field of biosensing. Finally, this paper provides an outlook on the development trends of biosensing technology in terms of portable high-precision SPR sensors, reduction of self-loss of thin film materials, optimization of image processing techniques and simplification of electrode modification for ECL sensors.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang Q
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China. wangqi@ise.neu.edu.cn. Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao 066004, P. R. China. State Key Laboratory of Synthetical Automation for Process Industries (Northeastern University), Shenyang 110819, P. R. China. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, P. R. China.
Ren ZH
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China. wangqi@ise.neu.edu.cn.
Zhao WM
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China. wangqi@ise.neu.edu.cn.
Wang L
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China. wangqi@ise.neu.edu.cn.
Yan X
College of Information Science and Engineering, Northeastern University, Shenyang 110819, China. wangqi@ise.neu.edu.cn.
Zhu AS
Basic Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
Qiu FM
Basic Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
Zhang KK
Institute of Oceanographic Instrumentation, Qilu University of Technology (Shandong Academy of Sciences), Qingdao 266061, P. R. China.

MeSH

Biosensing TechniquesNanostructuresSurface Plasmon Resonance

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34940766

Citation

Wang, Qi, et al. "Research Advances On Surface Plasmon Resonance Biosensors." Nanoscale, vol. 14, no. 3, 2022, pp. 564-591.
Wang Q, Ren ZH, Zhao WM, et al. Research advances on surface plasmon resonance biosensors. Nanoscale. 2022;14(3):564-591.
Wang, Q., Ren, Z. H., Zhao, W. M., Wang, L., Yan, X., Zhu, A. S., Qiu, F. M., & Zhang, K. K. (2022). Research advances on surface plasmon resonance biosensors. Nanoscale, 14(3), 564-591. https://doi.org/10.1039/d1nr05400g
Wang Q, et al. Research Advances On Surface Plasmon Resonance Biosensors. Nanoscale. 2022 Jan 20;14(3):564-591. PubMed PMID: 34940766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Research advances on surface plasmon resonance biosensors. AU - Wang,Qi, AU - Ren,Zi-Han, AU - Zhao,Wan-Ming, AU - Wang,Lei, AU - Yan,Xin, AU - Zhu,Ai-Song, AU - Qiu,Feng-Mei, AU - Zhang,Ke-Ke, Y1 - 2022/01/20/ PY - 2021/12/24/pubmed PY - 2022/1/27/medline PY - 2021/12/23/entrez SP - 564 EP - 591 JF - Nanoscale JO - Nanoscale VL - 14 IS - 3 N2 - The surface plasmon resonance (SPR) phenomenon is of wide interest due to its sensitivity to changes in surface refractive index for the label-free, highly sensitive and rapid detection of biomarkers. This paper reviews research progress on SPR biosensors modified with different substrate structures and surface materials, surface plasmon resonance imaging (SPRI), and SPR-enhanced electrochemiluminescent (ECL) biosensors for applications in biosensing in the last five years. This paper focuses on the research on the application of the SPR phenomenon in the field of bio-detection, reviews the sensing characteristics of SPR biosensors with substrate structures of prisms, gratings, and optical fibers, and summarizes and analyzes the sensitivity and interference resistance of SPR sensors with surface modification of different materials (high-refractive index dielectric films, metallic micro- and nanostructures, and surface antifouling materials). Considering that imaging is an important tool for biomedical detection, this paper reviews the research progress on SPRI technology in the field of biomedical detection. In addition, this paper also reviews the research progress on SPR-enhanced ECL biosensors in the field of biosensing. Finally, this paper provides an outlook on the development trends of biosensing technology in terms of portable high-precision SPR sensors, reduction of self-loss of thin film materials, optimization of image processing techniques and simplification of electrode modification for ECL sensors. SN - 2040-3372 UR - https://www.unboundmedicine.com/medline/citation/34940766/Research_advances_on_surface_plasmon_resonance_biosensors_ DB - PRIME DP - Unbound Medicine ER -