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Autonomic symptoms are predictive of dementia with Lewy bodies.
Parkinsonism Relat Disord. 2022 02; 95:1-4.PR

Abstract

INTRODUCTION

Autonomic symptoms are common in patients with dementia with Lewy bodies (DLB). Although autonomic dysfunction is considered as one of the primary early markers in patients with DLB, there are few studies that examine the timing of the onset of autonomic symptoms in these patients. The purpose of the current study was to evaluate the time of onset of autonomic symptoms in patients with DLB using a questionnaire.

METHODS

Autonomic symptoms were evaluated in patients with DLB using the Scales for Outcomes in Parkinson's disease - autonomic (SCOPA-Aut) questionnaire. Time of the onset of autonomic symptoms of patients with DLB was also assessed relative to that of memory loss.

RESULTS

A total of 106 patients with DLB were included. The most frequent symptom of dysautonomia in patients with DLB was constipation (60.4%), followed by orthostatic dizziness (33%), urinary frequency (30.2%), and daytime hyperhidrosis (22.6%). The gastrointestinal system was the most prominent system of autonomic dysfunction in patients with DLB. Orthostatic dizziness, daytime hyperhidrosis, and constipation all preceded the onset of memory loss by 0.2 ± 4.9, 3.3 ± 8.6, and 3.7 ± 9.2 years, respectively, while urinary incontinence occurred 1.7 ± 1.5 years following the onset of memory loss.

CONCLUSION

Many autonomic symptoms precede the onset of memory loss in patients with DLB, especially constipation and daytime hyperhidrosis. These symptoms can facilitate an early diagnosis of patients with DLB.

Authors+Show Affiliations

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.Department of Neurology and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.Graduate School of Tianjin Medical University, Tianjin, China; Department of Neurology, Yuncheng Central Hospital of Shanxi Province, Yuncheng, China.Graduate School of Tianjin Medical University, Tianjin, China.Graduate School of Tianjin Medical University, Tianjin, China.Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.Department of Neurology and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.Department of Neurology and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology and Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China. Electronic address: jiyongusa@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34942564

Citation

Hu, Wenzheng, et al. "Autonomic Symptoms Are Predictive of Dementia With Lewy Bodies." Parkinsonism & Related Disorders, vol. 95, 2022, pp. 1-4.
Hu W, Liu S, Wang F, et al. Autonomic symptoms are predictive of dementia with Lewy bodies. Parkinsonism Relat Disord. 2022;95:1-4.
Hu, W., Liu, S., Wang, F., Zhu, H., Du, X., Ma, L., Gan, J., Wu, H., Wang, X., & Ji, Y. (2022). Autonomic symptoms are predictive of dementia with Lewy bodies. Parkinsonism & Related Disorders, 95, 1-4. https://doi.org/10.1016/j.parkreldis.2021.11.023
Hu W, et al. Autonomic Symptoms Are Predictive of Dementia With Lewy Bodies. Parkinsonism Relat Disord. 2022;95:1-4. PubMed PMID: 34942564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic symptoms are predictive of dementia with Lewy bodies. AU - Hu,Wenzheng, AU - Liu,Shuai, AU - Wang,Fei, AU - Zhu,Han, AU - Du,Xiaoshan, AU - Ma,Lingyun, AU - Gan,Jinghuan, AU - Wu,Hao, AU - Wang,Xiaodan, AU - Ji,Yong, Y1 - 2021/11/27/ PY - 2021/02/13/received PY - 2021/11/18/revised PY - 2021/11/21/accepted PY - 2021/12/24/pubmed PY - 2021/12/24/medline PY - 2021/12/23/entrez KW - Alzheimer's disease KW - Autonomic symptoms KW - Dementia with Lewy bodies KW - Early diagnosis KW - SCOPA-Aut SP - 1 EP - 4 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 95 N2 - INTRODUCTION: Autonomic symptoms are common in patients with dementia with Lewy bodies (DLB). Although autonomic dysfunction is considered as one of the primary early markers in patients with DLB, there are few studies that examine the timing of the onset of autonomic symptoms in these patients. The purpose of the current study was to evaluate the time of onset of autonomic symptoms in patients with DLB using a questionnaire. METHODS: Autonomic symptoms were evaluated in patients with DLB using the Scales for Outcomes in Parkinson's disease - autonomic (SCOPA-Aut) questionnaire. Time of the onset of autonomic symptoms of patients with DLB was also assessed relative to that of memory loss. RESULTS: A total of 106 patients with DLB were included. The most frequent symptom of dysautonomia in patients with DLB was constipation (60.4%), followed by orthostatic dizziness (33%), urinary frequency (30.2%), and daytime hyperhidrosis (22.6%). The gastrointestinal system was the most prominent system of autonomic dysfunction in patients with DLB. Orthostatic dizziness, daytime hyperhidrosis, and constipation all preceded the onset of memory loss by 0.2 ± 4.9, 3.3 ± 8.6, and 3.7 ± 9.2 years, respectively, while urinary incontinence occurred 1.7 ± 1.5 years following the onset of memory loss. CONCLUSION: Many autonomic symptoms precede the onset of memory loss in patients with DLB, especially constipation and daytime hyperhidrosis. These symptoms can facilitate an early diagnosis of patients with DLB. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/34942564/Autonomic_symptoms_are_predictive_of_dementia_with_Lewy_bodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(21)00430-2 DB - PRIME DP - Unbound Medicine ER -