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Ginsenoside Rd: A promising natural neuroprotective agent.
Phytomedicine. 2022 Jan; 95:153883.P

Abstract

BACKGROUND

Neurological diseases seriously affect human health, which are arousing wider attention, and it is a great challenge to discover neuroprotective drugs with minimal side-effects and better efficacies. Natural agents derived from herbs or plants have become unparalleled resources for the discovery of novel drug candidates. Panax ginseng C. A. Meyer, a well-known herbal medicine in China, occupies a very important position in traditional Chinese medicines (TCMs) with a long history of clinical application. Ginsenoside Rd is the active compound in P. ginseng known to have broad-spectrum pharmacological effects to reduce neurological damage that can lead to neurological diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, cognitive impairment, and cerebral ischemia.

PURPOSE

To review and discuss the effects and mechanisms of ginsenoside Rd in the treatment of neurological diseases.

STUDY DESIGN & METHODS

The related information was compiled by the major scientific databases, such as Chinese National Knowledge Infrastructure (CNKI), Elsevier, ScienceDirect, PubMed, SpringerLink, Web of Science, and GeenMedical. Using 'Ginsenoside Rd', 'Ginsenosides', 'Anti-inflammation', 'Antioxidant', 'Apoptosis' and 'Neuroprotection' as keywords, the correlated literature was extracted and conducted from the databases mentioned above.

RESULTS

Through summarizing the existing research progress, we found that the general effects of ginsenoside Rd are anti-inflammatory, antioxidant, anti-apoptosis, inhibition of Ca2+ influx and protection of mitochondria, and through these pathways, the compound can inhibit excitatory toxicity, regulate nerve growth factor, and promote nerve regeneration.

CONCLUSION

Ginsenoside Rd is a promising natural neuroprotective agent. This review would contribute to the future development of ginsenoside Rd as a novel clinical candidate drug for treating neurological diseases.

Authors+Show Affiliations

Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: luanxin@shutcm.edu.cn.TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China. Electronic address: tangjy@cdutcm.edu.cn.Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: zhanghong@shutcm.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34952508

Citation

Chen, Yu-Ying, et al. "Ginsenoside Rd: a Promising Natural Neuroprotective Agent." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 95, 2022, p. 153883.
Chen YY, Liu QP, An P, et al. Ginsenoside Rd: A promising natural neuroprotective agent. Phytomedicine. 2022;95:153883.
Chen, Y. Y., Liu, Q. P., An, P., Jia, M., Luan, X., Tang, J. Y., & Zhang, H. (2022). Ginsenoside Rd: A promising natural neuroprotective agent. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 95, 153883. https://doi.org/10.1016/j.phymed.2021.153883
Chen YY, et al. Ginsenoside Rd: a Promising Natural Neuroprotective Agent. Phytomedicine. 2022;95:153883. PubMed PMID: 34952508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ginsenoside Rd: A promising natural neuroprotective agent. AU - Chen,Yu-Ying, AU - Liu,Qiu-Ping, AU - An,Pei, AU - Jia,Min, AU - Luan,Xin, AU - Tang,Jian-Yuan, AU - Zhang,Hong, Y1 - 2021/12/08/ PY - 2021/08/10/received PY - 2021/11/05/revised PY - 2021/12/05/accepted PY - 2021/12/25/pubmed PY - 2022/1/18/medline PY - 2021/12/24/entrez KW - Ginsenoside Rd KW - Mechanism KW - Neuroprotection KW - Panax ginseng KW - Signal pathway SP - 153883 EP - 153883 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 95 N2 - BACKGROUND: Neurological diseases seriously affect human health, which are arousing wider attention, and it is a great challenge to discover neuroprotective drugs with minimal side-effects and better efficacies. Natural agents derived from herbs or plants have become unparalleled resources for the discovery of novel drug candidates. Panax ginseng C. A. Meyer, a well-known herbal medicine in China, occupies a very important position in traditional Chinese medicines (TCMs) with a long history of clinical application. Ginsenoside Rd is the active compound in P. ginseng known to have broad-spectrum pharmacological effects to reduce neurological damage that can lead to neurological diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, cognitive impairment, and cerebral ischemia. PURPOSE: To review and discuss the effects and mechanisms of ginsenoside Rd in the treatment of neurological diseases. STUDY DESIGN & METHODS: The related information was compiled by the major scientific databases, such as Chinese National Knowledge Infrastructure (CNKI), Elsevier, ScienceDirect, PubMed, SpringerLink, Web of Science, and GeenMedical. Using 'Ginsenoside Rd', 'Ginsenosides', 'Anti-inflammation', 'Antioxidant', 'Apoptosis' and 'Neuroprotection' as keywords, the correlated literature was extracted and conducted from the databases mentioned above. RESULTS: Through summarizing the existing research progress, we found that the general effects of ginsenoside Rd are anti-inflammatory, antioxidant, anti-apoptosis, inhibition of Ca2+ influx and protection of mitochondria, and through these pathways, the compound can inhibit excitatory toxicity, regulate nerve growth factor, and promote nerve regeneration. CONCLUSION: Ginsenoside Rd is a promising natural neuroprotective agent. This review would contribute to the future development of ginsenoside Rd as a novel clinical candidate drug for treating neurological diseases. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/34952508/Ginsenoside_Rd:_A_promising_natural_neuroprotective_agent_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(21)00423-2 DB - PRIME DP - Unbound Medicine ER -