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Norovirus: Facts and Reflections from Past, Present, and Future.
Viruses. 2021 11 30; 13(12)V

Abstract

Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the "Norwalk virus" by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral-host-microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.

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Authors+Show Affiliations

Lucero Y
Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile. Hospital Dr. Roberto del Río Hospital, Department of Pediatrics and Pediatric Surgery (Northern Campus), Faculty of Medicine, Universidad de Chile, Santiago 8380418, Chile. Clínica Alemana de Santiago, Faculty of Medicine, Universidad del Desarrollo-Clínica Alemana, Santiago 7650568, Chile.
Matson DO
Eastern Shore Health Department, Virginia Department of Public Health, Accomack County, VA 23301, USA.
Ashkenazi S
Adelson School of Medicine, Ariel University, Ariel 40700, Israel. Department of Pediatrics A, Schneider Children's Medical Center, Petach Tikva 49202, Israel.
George S
Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
O'Ryan M
Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.

MeSH

Antiviral AgentsCOVID-19Caliciviridae InfectionsGastroenteritisGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansNorovirusSARS-CoV-2Viral Vaccines

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34960668

Citation

Lucero, Yalda, et al. "Norovirus: Facts and Reflections From Past, Present, and Future." Viruses, vol. 13, no. 12, 2021.
Lucero Y, Matson DO, Ashkenazi S, et al. Norovirus: Facts and Reflections from Past, Present, and Future. Viruses. 2021;13(12).
Lucero, Y., Matson, D. O., Ashkenazi, S., George, S., & O'Ryan, M. (2021). Norovirus: Facts and Reflections from Past, Present, and Future. Viruses, 13(12). https://doi.org/10.3390/v13122399
Lucero Y, et al. Norovirus: Facts and Reflections From Past, Present, and Future. Viruses. 2021 11 30;13(12) PubMed PMID: 34960668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Norovirus: Facts and Reflections from Past, Present, and Future. AU - Lucero,Yalda, AU - Matson,David O, AU - Ashkenazi,Shai, AU - George,Sergio, AU - O'Ryan,Miguel, Y1 - 2021/11/30/ PY - 2021/10/21/received PY - 2021/11/18/revised PY - 2021/11/23/accepted PY - 2021/12/28/entrez PY - 2021/12/29/pubmed PY - 2022/1/7/medline KW - Norovirus KW - epidemiology KW - prevention KW - vaccine JF - Viruses JO - Viruses VL - 13 IS - 12 N2 - Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the "Norwalk virus" by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral-host-microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/34960668/Norovirus:_Facts_and_Reflections_from_Past_Present_and_Future_ DB - PRIME DP - Unbound Medicine ER -