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Increase of HLA-DR7 in pigeon breeder's lung in a Mexican population.
Clin Immunol Immunopathol. 1987 Jul; 44(1):63-70.CI

Abstract

The phenotypes of the major histocompatibility complex, loci A, B, C, and DR, were studied in 48 patients with hypersensitivity pneumonitis induced by avian antigen (pigeon breeder's lung) and the results were compared to those obtained from 200 normal subjects of similar ethnic background. Furthermore, we analyzed the delta values of the observed and expected frequencies in the deduced haplotypes of the affected population. Our results showed a significant increase of the antigen HLA-DR7 (corrected P less than 0.001) in patients with pigeon breeder's lung and an equally important difference in the delta values of the haplotypes A1-B8, A25-B14, B35-DR4, and B4-DR5. In addition, the phenotypes of locus DQ were analyzed in 21 patients and 20 controls and no apparent differences were observed. These results suggest that a multifactorial genetic susceptibility associated at least in part with the major histocompatibility complex plays in important role in the development of this disease.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3496181

Citation

Selman, M, et al. "Increase of HLA-DR7 in Pigeon Breeder's Lung in a Mexican Population." Clinical Immunology and Immunopathology, vol. 44, no. 1, 1987, pp. 63-70.
Selman M, Terán L, Mendoza A, et al. Increase of HLA-DR7 in pigeon breeder's lung in a Mexican population. Clin Immunol Immunopathol. 1987;44(1):63-70.
Selman, M., Terán, L., Mendoza, A., Camarena, A., Martínez-Cordero, E., Lezama, M., & Rubio, H. M. (1987). Increase of HLA-DR7 in pigeon breeder's lung in a Mexican population. Clinical Immunology and Immunopathology, 44(1), 63-70.
Selman M, et al. Increase of HLA-DR7 in Pigeon Breeder's Lung in a Mexican Population. Clin Immunol Immunopathol. 1987;44(1):63-70. PubMed PMID: 3496181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase of HLA-DR7 in pigeon breeder's lung in a Mexican population. AU - Selman,M, AU - Terán,L, AU - Mendoza,A, AU - Camarena,A, AU - Martínez-Cordero,E, AU - Lezama,M, AU - Rubio,H M, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 63 EP - 70 JF - Clinical immunology and immunopathology JO - Clin Immunol Immunopathol VL - 44 IS - 1 N2 - The phenotypes of the major histocompatibility complex, loci A, B, C, and DR, were studied in 48 patients with hypersensitivity pneumonitis induced by avian antigen (pigeon breeder's lung) and the results were compared to those obtained from 200 normal subjects of similar ethnic background. Furthermore, we analyzed the delta values of the observed and expected frequencies in the deduced haplotypes of the affected population. Our results showed a significant increase of the antigen HLA-DR7 (corrected P less than 0.001) in patients with pigeon breeder's lung and an equally important difference in the delta values of the haplotypes A1-B8, A25-B14, B35-DR4, and B4-DR5. In addition, the phenotypes of locus DQ were analyzed in 21 patients and 20 controls and no apparent differences were observed. These results suggest that a multifactorial genetic susceptibility associated at least in part with the major histocompatibility complex plays in important role in the development of this disease. SN - 0090-1229 UR - https://www.unboundmedicine.com/medline/citation/3496181/Increase_of_HLA_DR7_in_pigeon_breeder's_lung_in_a_Mexican_population_ L2 - https://antibodies.cancer.gov/detail/CPTC-HLA-DPB1-2 DB - PRIME DP - Unbound Medicine ER -