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[Prophylactic sclerosing of esophageal varices. Results of a prospective randomized 7-year longitudinal study].
Dtsch Med Wochenschr. 1987 Jun 12; 112(24):947-51.DM

Abstract

Over a period of six years, esophageal varices (stage III or IV) were endoscopically diagnosed in 49 patients with confirmed liver cirrhosis and no previous bleeding. Prophylactic sclerotherapy of the esophageal varices was performed in 25 patients, while 24 were treated conservatively (control group). The groups were comparable as to duration, cause and severity of the cirrhosis, but differed in sex distribution. The patients had been followed for at least two, maximally seven, years (median 44 months). Only five bleedings occurred in the prophylactic sclerotherapy group, 15 in the control group during the entire observation period. Among the control group eight patients died due to bleeding, compared to only one in the sclerotherapy group; but there were eight deaths in the control group, 13 in the sclerotherapy group from other complications of liver cirrhosis. Survival rate was higher in the sclerotherapy group, especially in the first year and with alcoholic cirrhosis. There were no serious complications from the sclerotherapy. It is concluded that prophylactic sclerotherapy clearly reduces the number of bleedings from varices, but improvement in prognosis is relatively short.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

3496202

Citation

Wördehoff, D, and H J. Spech. "[Prophylactic Sclerosing of Esophageal Varices. Results of a Prospective Randomized 7-year Longitudinal Study]." Deutsche Medizinische Wochenschrift (1946), vol. 112, no. 24, 1987, pp. 947-51.
Wördehoff D, Spech HJ. [Prophylactic sclerosing of esophageal varices. Results of a prospective randomized 7-year longitudinal study]. Dtsch Med Wochenschr. 1987;112(24):947-51.
Wördehoff, D., & Spech, H. J. (1987). [Prophylactic sclerosing of esophageal varices. Results of a prospective randomized 7-year longitudinal study]. Deutsche Medizinische Wochenschrift (1946), 112(24), 947-51.
Wördehoff D, Spech HJ. [Prophylactic Sclerosing of Esophageal Varices. Results of a Prospective Randomized 7-year Longitudinal Study]. Dtsch Med Wochenschr. 1987 Jun 12;112(24):947-51. PubMed PMID: 3496202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prophylactic sclerosing of esophageal varices. Results of a prospective randomized 7-year longitudinal study]. AU - Wördehoff,D, AU - Spech,H J, PY - 1987/6/12/pubmed PY - 1987/6/12/medline PY - 1987/6/12/entrez SP - 947 EP - 51 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 112 IS - 24 N2 - Over a period of six years, esophageal varices (stage III or IV) were endoscopically diagnosed in 49 patients with confirmed liver cirrhosis and no previous bleeding. Prophylactic sclerotherapy of the esophageal varices was performed in 25 patients, while 24 were treated conservatively (control group). The groups were comparable as to duration, cause and severity of the cirrhosis, but differed in sex distribution. The patients had been followed for at least two, maximally seven, years (median 44 months). Only five bleedings occurred in the prophylactic sclerotherapy group, 15 in the control group during the entire observation period. Among the control group eight patients died due to bleeding, compared to only one in the sclerotherapy group; but there were eight deaths in the control group, 13 in the sclerotherapy group from other complications of liver cirrhosis. Survival rate was higher in the sclerotherapy group, especially in the first year and with alcoholic cirrhosis. There were no serious complications from the sclerotherapy. It is concluded that prophylactic sclerotherapy clearly reduces the number of bleedings from varices, but improvement in prognosis is relatively short. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/3496202/[Prophylactic_sclerosing_of_esophageal_varices__Results_of_a_prospective_randomized_7_year_longitudinal_study]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1068172 DB - PRIME DP - Unbound Medicine ER -