Tags

Type your tag names separated by a space and hit enter

NMR spectroscopy for structural elucidation of sulfated polysaccharides from red seaweeds.
Int J Biol Macromol. 2022 Feb 28; 199:386-400.IJ

Abstract

Some sulfated polysaccharides from red seaweeds are used as hydrocolloids. In addition, it is well known that there are sulfated galactans (carrageenans and agarans) and sulfated mannans, with remarkable biological properties, as antiviral, antitumoral, immunomodulating, antiangiogenic, antioxidant, anticoagulant, and antithrombotic activities, and so on. Knowledge of the detailed structure of the active compound is essential and difficult to acquire. The substitution patterns of the polymer chain, as degree of sulfation and position of sulfate groups, as well as other substituents of the backbone, determine their biological behavior. NMR spectroscopy is a powerful and versatile tool for structural determination. It can be used for elucidation of structures of polysaccharides from new algal sources with novel substitutions or to detect the already known structures from different algal sources, and it could even help to monitor the quality of the active compound on a productive scale. In this review, the available information about NMR spectroscopy of sulfated polysaccharides from red seaweeds is revised and rationalized, to help other researchers working in different fields to study their structures. In addition, considerations about the effects of different structural features, as well as some recording conditions on the chemical shifts of the signals are analyzed.

Authors+Show Affiliations

Universidad de Buenos Aires, Facultad de Agronomía, Departamento de Biología Aplicada y Alimentos, Cátedra de Química de Biomoléculas, Av. San Martín 4453, C1417DSE Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Centro de Investigación de Hidratos de Carbono (CIHIDECAR), Ciudad Universitaria - Pabellón 2, C1428EHA Buenos Aires, Argentina. Electronic address: rodriguezr@qo.fcen.uba.ar.CONICET-Universidad de Buenos Aires, Centro de Investigación de Hidratos de Carbono (CIHIDECAR), Ciudad Universitaria - Pabellón 2, C1428EHA Buenos Aires, Argentina. Electronic address: cristina@qo.fcen.uba.ar.Universidad de Buenos Aires, Facultad de Agronomía, Departamento de Biología Aplicada y Alimentos, Cátedra de Química de Biomoléculas, Av. San Martín 4453, C1417DSE Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Centro de Investigación de Hidratos de Carbono (CIHIDECAR), Ciudad Universitaria - Pabellón 2, C1428EHA Buenos Aires, Argentina. Electronic address: ciancia@agro.uba.ar.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34973978

Citation

Rodríguez Sánchez, Rodrigo A., et al. "NMR Spectroscopy for Structural Elucidation of Sulfated Polysaccharides From Red Seaweeds." International Journal of Biological Macromolecules, vol. 199, 2022, pp. 386-400.
Rodríguez Sánchez RA, Matulewicz MC, Ciancia M. NMR spectroscopy for structural elucidation of sulfated polysaccharides from red seaweeds. Int J Biol Macromol. 2022;199:386-400.
Rodríguez Sánchez, R. A., Matulewicz, M. C., & Ciancia, M. (2022). NMR spectroscopy for structural elucidation of sulfated polysaccharides from red seaweeds. International Journal of Biological Macromolecules, 199, 386-400. https://doi.org/10.1016/j.ijbiomac.2021.12.080
Rodríguez Sánchez RA, Matulewicz MC, Ciancia M. NMR Spectroscopy for Structural Elucidation of Sulfated Polysaccharides From Red Seaweeds. Int J Biol Macromol. 2022 Feb 28;199:386-400. PubMed PMID: 34973978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMR spectroscopy for structural elucidation of sulfated polysaccharides from red seaweeds. AU - Rodríguez Sánchez,Rodrigo A, AU - Matulewicz,María C, AU - Ciancia,Marina, Y1 - 2021/12/30/ PY - 2021/06/19/received PY - 2021/12/08/revised PY - 2021/12/13/accepted PY - 2022/1/3/pubmed PY - 2022/4/1/medline PY - 2022/1/2/entrez KW - NMR Spectroscopy KW - Red seaweeds KW - Sulfated polysaccharides SP - 386 EP - 400 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 199 N2 - Some sulfated polysaccharides from red seaweeds are used as hydrocolloids. In addition, it is well known that there are sulfated galactans (carrageenans and agarans) and sulfated mannans, with remarkable biological properties, as antiviral, antitumoral, immunomodulating, antiangiogenic, antioxidant, anticoagulant, and antithrombotic activities, and so on. Knowledge of the detailed structure of the active compound is essential and difficult to acquire. The substitution patterns of the polymer chain, as degree of sulfation and position of sulfate groups, as well as other substituents of the backbone, determine their biological behavior. NMR spectroscopy is a powerful and versatile tool for structural determination. It can be used for elucidation of structures of polysaccharides from new algal sources with novel substitutions or to detect the already known structures from different algal sources, and it could even help to monitor the quality of the active compound on a productive scale. In this review, the available information about NMR spectroscopy of sulfated polysaccharides from red seaweeds is revised and rationalized, to help other researchers working in different fields to study their structures. In addition, considerations about the effects of different structural features, as well as some recording conditions on the chemical shifts of the signals are analyzed. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/34973978/NMR_spectroscopy_for_structural_elucidation_of_sulfated_polysaccharides_from_red_seaweeds_ DB - PRIME DP - Unbound Medicine ER -