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Gastric antral vascular ectasia. A histologic and morphometric study of "the watermelon stomach".
Am J Surg Pathol. 1987 Oct; 11(10):750-7.AJ

Abstract

Gastric antral vascular ectasia (GAVE) is an uncommon but important cause of gastrointestinal blood loss and iron deficiency anemia that is characterized by a distinctive endoscopic appearance consisting of parallel erythematous folds traversing the gastric antrum. In order to clarify the histologic features of this lesion, nine antral biopsy specimens from seven patients with the clinical and endoscopic diagnosis of GAVE were reviewed and compared with specimens from normal controls and patients with other common antral lesions. Specimens obtained using standard endoscopic biopsy forceps were evaluated for mucosal vascularity, presence of intravascular fibrin thrombi, and the following histologic changes: mucosal inflammation, fibromuscular hyperplasia of lamina propria, epithelial regeneration, and mucosal architectural distortion. Mucosal vascularity was determined by counting the absolute number of vascular lumina per slide, measuring the mean cross-sectional area of each vessel lumen, and determining the percentage of each specimen occupied by vessels. Histologic changes were graded as absent to minimal, moderate, or marked. Significant differences (p less than 0.05) between GAVE and control groups were mean vessel cross-sectional area, percentage of area occupied by vessels, presence of intravascular fibrin thrombi, and fibromuscular hyperplasia. GAVE appears to demonstrate sufficiently distinctive histopathologic features to allow its recognition in antral biopsy specimens obtained by endoscopy.

Authors+Show Affiliations

Department of Pathology, The Cleveland Clinic Foundation, OH 44106.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3499091

Citation

Suit, P F., et al. "Gastric Antral Vascular Ectasia. a Histologic and Morphometric Study of "the Watermelon Stomach"." The American Journal of Surgical Pathology, vol. 11, no. 10, 1987, pp. 750-7.
Suit PF, Petras RE, Bauer TW, et al. Gastric antral vascular ectasia. A histologic and morphometric study of "the watermelon stomach". Am J Surg Pathol. 1987;11(10):750-7.
Suit, P. F., Petras, R. E., Bauer, T. W., & Petrini, J. L. (1987). Gastric antral vascular ectasia. A histologic and morphometric study of "the watermelon stomach". The American Journal of Surgical Pathology, 11(10), 750-7.
Suit PF, et al. Gastric Antral Vascular Ectasia. a Histologic and Morphometric Study of "the Watermelon Stomach". Am J Surg Pathol. 1987;11(10):750-7. PubMed PMID: 3499091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric antral vascular ectasia. A histologic and morphometric study of "the watermelon stomach". AU - Suit,P F, AU - Petras,R E, AU - Bauer,T W, AU - Petrini,J L,Jr PY - 1987/10/1/pubmed PY - 2001/3/28/medline PY - 1987/10/1/entrez SP - 750 EP - 7 JF - The American journal of surgical pathology JO - Am. J. Surg. Pathol. VL - 11 IS - 10 N2 - Gastric antral vascular ectasia (GAVE) is an uncommon but important cause of gastrointestinal blood loss and iron deficiency anemia that is characterized by a distinctive endoscopic appearance consisting of parallel erythematous folds traversing the gastric antrum. In order to clarify the histologic features of this lesion, nine antral biopsy specimens from seven patients with the clinical and endoscopic diagnosis of GAVE were reviewed and compared with specimens from normal controls and patients with other common antral lesions. Specimens obtained using standard endoscopic biopsy forceps were evaluated for mucosal vascularity, presence of intravascular fibrin thrombi, and the following histologic changes: mucosal inflammation, fibromuscular hyperplasia of lamina propria, epithelial regeneration, and mucosal architectural distortion. Mucosal vascularity was determined by counting the absolute number of vascular lumina per slide, measuring the mean cross-sectional area of each vessel lumen, and determining the percentage of each specimen occupied by vessels. Histologic changes were graded as absent to minimal, moderate, or marked. Significant differences (p less than 0.05) between GAVE and control groups were mean vessel cross-sectional area, percentage of area occupied by vessels, presence of intravascular fibrin thrombi, and fibromuscular hyperplasia. GAVE appears to demonstrate sufficiently distinctive histopathologic features to allow its recognition in antral biopsy specimens obtained by endoscopy. SN - 0147-5185 UR - https://www.unboundmedicine.com/medline/citation/3499091/Gastric_antral_vascular_ectasia__A_histologic_and_morphometric_study_of_"the_watermelon_stomach"_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3499091.ui DB - PRIME DP - Unbound Medicine ER -