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Exercise and the antiparkinsonian response to levodopa.
Clin Neuropharmacol. 1987 Aug; 10(4):351-5.CN

Abstract

The contribution of acute physical exercise to the motor fluctuations occurring in advanced Parkinson's disease was studied in four patients using a standard treadmill protocol. With a constant optimal-dose intravenous levodopa infusion, no changes in plasma drug levels or antiparkinsonian response were observed during or for 60 min following a 35-min exercise period, during which the work load increased from minimal to vigorous. Although an effect of exercise on levodopa absorption from the gastrointestinal tract cannot be excluded, there seems to be no basis on which to implicate acute physical activity, at levels ordinarily experienced by parkinsonian patients, in the pathogenesis of the fluctuations in motor performance.

Authors+Show Affiliations

Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3503678

Citation

Mouradian, M M., et al. "Exercise and the Antiparkinsonian Response to Levodopa." Clinical Neuropharmacology, vol. 10, no. 4, 1987, pp. 351-5.
Mouradian MM, Juncos JL, Serrati C, et al. Exercise and the antiparkinsonian response to levodopa. Clin Neuropharmacol. 1987;10(4):351-5.
Mouradian, M. M., Juncos, J. L., Serrati, C., Fabbrini, G., Palmeri, S., & Chase, T. N. (1987). Exercise and the antiparkinsonian response to levodopa. Clinical Neuropharmacology, 10(4), 351-5.
Mouradian MM, et al. Exercise and the Antiparkinsonian Response to Levodopa. Clin Neuropharmacol. 1987;10(4):351-5. PubMed PMID: 3503678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise and the antiparkinsonian response to levodopa. AU - Mouradian,M M, AU - Juncos,J L, AU - Serrati,C, AU - Fabbrini,G, AU - Palmeri,S, AU - Chase,T N, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 351 EP - 5 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 10 IS - 4 N2 - The contribution of acute physical exercise to the motor fluctuations occurring in advanced Parkinson's disease was studied in four patients using a standard treadmill protocol. With a constant optimal-dose intravenous levodopa infusion, no changes in plasma drug levels or antiparkinsonian response were observed during or for 60 min following a 35-min exercise period, during which the work load increased from minimal to vigorous. Although an effect of exercise on levodopa absorption from the gastrointestinal tract cannot be excluded, there seems to be no basis on which to implicate acute physical activity, at levels ordinarily experienced by parkinsonian patients, in the pathogenesis of the fluctuations in motor performance. SN - 0362-5664 UR - https://www.unboundmedicine.com/medline/citation/3503678/Exercise_and_the_antiparkinsonian_response_to_levodopa_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3503678.ui DB - PRIME DP - Unbound Medicine ER -