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Evaluation of red cell volume distribution width (RDW).
Hematol Pathol. 1987; 1(2):117-23.HP

Abstract

The purpose of this study was to evaluate red cell distribution width (RDW) in the differential diagnosis of patients with well defined iron deficiency (ID), anemia of chronic disease (ACD), and thalassemia trait. Mean RDW in 100 "normals" was 13.1%. Elevated RDW (greater than 15.0%) was observed in 90% of ID (N = 39), 32% of ACD(N = 79), 66% of beta-thalassemia trait (N = 100), 53% of alpha-thalassemia trait men (N = 127), 34% of alpha-thalassemia trait women (N = 116), 3% of sickle cell trait (N = 101), and 88% of sickling disorders (N = 32). The Bessman classification by mean corpuscular volume and RDW was of limited value in separating ID from thalassemia trait but was improved by adopting 16.0% as the upper limit of normal for RDW. Although many attempts have been made to discriminate between ID and thalassemia trait on the basis of red cell values from a cell counter, none (including RDW) is sufficiently specific or sensitive to obviate the need for confirmation of the diagnosis by standard laboratory methods.

Authors+Show Affiliations

Department of Laboratory Medicine, Naval Hospital, San Diego, California.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3504434

Citation

Marsh, W L., et al. "Evaluation of Red Cell Volume Distribution Width (RDW)." Hematologic Pathology, vol. 1, no. 2, 1987, pp. 117-23.
Marsh WL, Bishop JW, Darcy TP. Evaluation of red cell volume distribution width (RDW). Hematol Pathol. 1987;1(2):117-23.
Marsh, W. L., Bishop, J. W., & Darcy, T. P. (1987). Evaluation of red cell volume distribution width (RDW). Hematologic Pathology, 1(2), 117-23.
Marsh WL, Bishop JW, Darcy TP. Evaluation of Red Cell Volume Distribution Width (RDW). Hematol Pathol. 1987;1(2):117-23. PubMed PMID: 3504434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of red cell volume distribution width (RDW). AU - Marsh,W L,Jr AU - Bishop,J W, AU - Darcy,T P, PY - 1987/1/1/pubmed PY - 2001/3/28/medline PY - 1987/1/1/entrez SP - 117 EP - 23 JF - Hematologic pathology JO - Hematol Pathol VL - 1 IS - 2 N2 - The purpose of this study was to evaluate red cell distribution width (RDW) in the differential diagnosis of patients with well defined iron deficiency (ID), anemia of chronic disease (ACD), and thalassemia trait. Mean RDW in 100 "normals" was 13.1%. Elevated RDW (greater than 15.0%) was observed in 90% of ID (N = 39), 32% of ACD(N = 79), 66% of beta-thalassemia trait (N = 100), 53% of alpha-thalassemia trait men (N = 127), 34% of alpha-thalassemia trait women (N = 116), 3% of sickle cell trait (N = 101), and 88% of sickling disorders (N = 32). The Bessman classification by mean corpuscular volume and RDW was of limited value in separating ID from thalassemia trait but was improved by adopting 16.0% as the upper limit of normal for RDW. Although many attempts have been made to discriminate between ID and thalassemia trait on the basis of red cell values from a cell counter, none (including RDW) is sufficiently specific or sensitive to obviate the need for confirmation of the diagnosis by standard laboratory methods. SN - 0886-0238 UR - https://www.unboundmedicine.com/medline/citation/3504434/Evaluation_of_red_cell_volume_distribution_width__RDW__ L2 - https://medlineplus.gov/anemia.html DB - PRIME DP - Unbound Medicine ER -