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Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial.
Clin Immunol. 2022 03; 236:108935.CI

Abstract

BACKGROUND

This study aimed to investigate the effects of combined spinal-epidural anesthesia (CSEA) with acupoint injection (AI) on the maternal-fetal expression of interleukin-1β (IL-1β), interleukin-10 (IL-10), analgesia effect, and labor outcomes.

METHODS

A total of 360 healthy primiparas were randomized into the CSEA+AI group, the CSEA group, the AI group, and the control group (n = 90, each group) according to the labor analgesia methods.

RESULTS

Compared to the CSEA group, the CSEA+AI group had significantly lower visual analog scale (VAS) scores, adverse events, dose of ropivacaine/sufentanil, and shorter labor durations. The IL-1β/IL-10 ratio in maternal peripheral blood and umbilical cord blood was reduced in the CSEA+AI group compared with the CSEA group.

CONCLUSION

The combination of CSEA and AI can reduce the ratio of IL-1β/ IL-10 in maternal peripheral blood and umbilical cord blood, which can effectively relieve labor pain.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wu L
Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China. Electronic address: wulingling2003@163.com.
Zhao H
Department of Gynecology, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034, Yunnan, China.
Zhang Z
Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
Huang M
Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
Wu S
Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
Fang C
Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
Wang R
Department of Anesthesiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
Li S
Department of Anesthesiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
Yi W
Acupuncture-Moxibustion and Rehabilitation Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Zhou A
Department of Clinical Medicine, the Second Clinical Medical School of Guangdong Medical University, Dongguan 523808, Guangdong, China.

MeSH

Acupuncture PointsAnalgesia, EpiduralAnalgesia, ObstetricalAnesthesia, EpiduralFemaleFetal BloodHumansInterleukin-10Interleukin-1betaPregnancyProspective Studies

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35093596

Citation

Wu, Lingling, et al. "Combined Spinal-epidural Anesthesia With Acupoint Injection for Labor Anesthesia Reduces IL-1β/IL-10 Ratio in Maternal Peripheral Blood, Umbilical Cord Blood and Improves the Labor Outcomes: a Prospective Randomized Controlled Trial." Clinical Immunology (Orlando, Fla.), vol. 236, 2022, p. 108935.
Wu L, Zhao H, Zhang Z, et al. Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial. Clin Immunol. 2022;236:108935.
Wu, L., Zhao, H., Zhang, Z., Huang, M., Wu, S., Fang, C., Wang, R., Li, S., Yi, W., & Zhou, A. (2022). Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial. Clinical Immunology (Orlando, Fla.), 236, 108935. https://doi.org/10.1016/j.clim.2022.108935
Wu L, et al. Combined Spinal-epidural Anesthesia With Acupoint Injection for Labor Anesthesia Reduces IL-1β/IL-10 Ratio in Maternal Peripheral Blood, Umbilical Cord Blood and Improves the Labor Outcomes: a Prospective Randomized Controlled Trial. Clin Immunol. 2022;236:108935. PubMed PMID: 35093596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial. AU - Wu,Lingling, AU - Zhao,Haiyan, AU - Zhang,Zijing, AU - Huang,Minli, AU - Wu,Shuzhen, AU - Fang,Changping, AU - Wang,Ren, AU - Li,Shangrong, AU - Yi,Wei, AU - Zhou,Andong, Y1 - 2022/01/31/ PY - 2021/01/25/received PY - 2021/11/29/revised PY - 2022/01/19/accepted PY - 2022/1/31/pubmed PY - 2022/5/7/medline PY - 2022/1/30/entrez KW - Acupoint injection KW - Combined spinal-epidural anesthesia KW - Interleukin-10 KW - Interleukin-1β KW - Labor analgesia KW - Labor outcome SP - 108935 EP - 108935 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 236 N2 - BACKGROUND: This study aimed to investigate the effects of combined spinal-epidural anesthesia (CSEA) with acupoint injection (AI) on the maternal-fetal expression of interleukin-1β (IL-1β), interleukin-10 (IL-10), analgesia effect, and labor outcomes. METHODS: A total of 360 healthy primiparas were randomized into the CSEA+AI group, the CSEA group, the AI group, and the control group (n = 90, each group) according to the labor analgesia methods. RESULTS: Compared to the CSEA group, the CSEA+AI group had significantly lower visual analog scale (VAS) scores, adverse events, dose of ropivacaine/sufentanil, and shorter labor durations. The IL-1β/IL-10 ratio in maternal peripheral blood and umbilical cord blood was reduced in the CSEA+AI group compared with the CSEA group. CONCLUSION: The combination of CSEA and AI can reduce the ratio of IL-1β/ IL-10 in maternal peripheral blood and umbilical cord blood, which can effectively relieve labor pain. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/35093596/Combined_spinal_epidural_anesthesia_with_acupoint_injection_for_labor_anesthesia_reduces_IL_1β/IL_10_ratio_in_maternal_peripheral_blood_umbilical_cord_blood_and_improves_the_labor_outcomes:_A_prospective_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -