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Studies on the pathogenesis of Salmonella typhimurium and Salmonella choleraesuis var kunzendorf infection in weanling pigs.
Am J Vet Res. 1986 Jan; 47(1):75-83.AJ

Abstract

Twenty-six 4-week-old pigs were randomly allotted to 4 groups: group 1--orally inoculated with Salmonella typhimurium; group 2--orally dosed with S choleraesuis; and groups 3 and 4, with surgically constructed intestinal loops--loops inoculated with either S typhimurium or S choleraesuis. One pig each from groups 1 and 2 was killed at 8, 12, 24, 48, 72, 96, and 120 hours after inoculation. One pig each from groups 3 and 4 was killed at 2, 4, 6, 8, 12, and 24 hours after intestinal loop inoculation. Inoculation of S typhimurium resulted in acute enterocolitis of variable severity, whereas inoculation of S choleraesuis resulted initially in septicemia followed by formation of large necrotic and ulcerative lesions in the colonic mucosa. The most consistent systemic lesion of S choleraesuis infection was interstitial pneumonia and multifocal hepatic necrosis. Salmonella typhimurium and S choleraesuis were ultrastructurally within enterocytes of ligated ileal loops. Intracellular bacteria were morphologically intact, occurred free in the cytoplasm and membrane bound, and caused no detectable cytotoxic effect to the cell. Both S typhimurium and S choleraesuis penetrated the intestinal mucosa and were isolated from mesenteric lymph nodes at 2 hours after inoculation.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3511804

Citation

Reed, W M., et al. "Studies On the Pathogenesis of Salmonella Typhimurium and Salmonella Choleraesuis Var Kunzendorf Infection in Weanling Pigs." American Journal of Veterinary Research, vol. 47, no. 1, 1986, pp. 75-83.
Reed WM, Olander HJ, Thacker HL. Studies on the pathogenesis of Salmonella typhimurium and Salmonella choleraesuis var kunzendorf infection in weanling pigs. Am J Vet Res. 1986;47(1):75-83.
Reed, W. M., Olander, H. J., & Thacker, H. L. (1986). Studies on the pathogenesis of Salmonella typhimurium and Salmonella choleraesuis var kunzendorf infection in weanling pigs. American Journal of Veterinary Research, 47(1), 75-83.
Reed WM, Olander HJ, Thacker HL. Studies On the Pathogenesis of Salmonella Typhimurium and Salmonella Choleraesuis Var Kunzendorf Infection in Weanling Pigs. Am J Vet Res. 1986;47(1):75-83. PubMed PMID: 3511804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the pathogenesis of Salmonella typhimurium and Salmonella choleraesuis var kunzendorf infection in weanling pigs. AU - Reed,W M, AU - Olander,H J, AU - Thacker,H L, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 75 EP - 83 JF - American journal of veterinary research JO - Am J Vet Res VL - 47 IS - 1 N2 - Twenty-six 4-week-old pigs were randomly allotted to 4 groups: group 1--orally inoculated with Salmonella typhimurium; group 2--orally dosed with S choleraesuis; and groups 3 and 4, with surgically constructed intestinal loops--loops inoculated with either S typhimurium or S choleraesuis. One pig each from groups 1 and 2 was killed at 8, 12, 24, 48, 72, 96, and 120 hours after inoculation. One pig each from groups 3 and 4 was killed at 2, 4, 6, 8, 12, and 24 hours after intestinal loop inoculation. Inoculation of S typhimurium resulted in acute enterocolitis of variable severity, whereas inoculation of S choleraesuis resulted initially in septicemia followed by formation of large necrotic and ulcerative lesions in the colonic mucosa. The most consistent systemic lesion of S choleraesuis infection was interstitial pneumonia and multifocal hepatic necrosis. Salmonella typhimurium and S choleraesuis were ultrastructurally within enterocytes of ligated ileal loops. Intracellular bacteria were morphologically intact, occurred free in the cytoplasm and membrane bound, and caused no detectable cytotoxic effect to the cell. Both S typhimurium and S choleraesuis penetrated the intestinal mucosa and were isolated from mesenteric lymph nodes at 2 hours after inoculation. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/3511804/Studies_on_the_pathogenesis_of_Salmonella_typhimurium_and_Salmonella_choleraesuis_var_kunzendorf_infection_in_weanling_pigs_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:3511804 DB - PRIME DP - Unbound Medicine ER -