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Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine.
Am Rev Respir Dis. 1986 Feb; 133(2):252-4.AR

Abstract

In the bronchi of asthmatic subjects many bronchoconstrictor mediators and neurotransmitters might be released together, and therefore, potential interactions might occur that could be important in airway hyperreactivity. We have studied the effect of inhaled methacholine, bradykinin, and prostaglandin D2 (PGD2) on bronchial reactivity to inhaled histamine in 6 mild asthmatic subjects, 22 to 36 yr of age. All of the test spasmogens were given at equivalent bronchoconstricting concentrations. Simultaneous dosing with PGD2 caused a significant increase in reactivity to histamine, mean dose of histamine causing a 35% fall in specific airway conductance being 0.72 mumol before, and 0.32 mumol with, PGD2; (p less than 0.01). This was not seen with histamine itself, methacholine, or bradykinin. Prostaglandin D2 caused a similar increase in bronchial reactivity to inhaled methacholine, suggesting a postreceptor potentiation of airway smooth muscle contractility. This positive interaction between inflammatory mediators known to be released in asthma has important implications for understanding bronchial hyperreactivity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3511806

Citation

Fuller, R W., et al. "Prostaglandin D2 Potentiates Airway Responsiveness to Histamine and Methacholine." The American Review of Respiratory Disease, vol. 133, no. 2, 1986, pp. 252-4.
Fuller RW, Dixon CM, Dollery CT, et al. Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. Am Rev Respir Dis. 1986;133(2):252-4.
Fuller, R. W., Dixon, C. M., Dollery, C. T., & Barnes, P. J. (1986). Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. The American Review of Respiratory Disease, 133(2), 252-4.
Fuller RW, et al. Prostaglandin D2 Potentiates Airway Responsiveness to Histamine and Methacholine. Am Rev Respir Dis. 1986;133(2):252-4. PubMed PMID: 3511806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. AU - Fuller,R W, AU - Dixon,C M, AU - Dollery,C T, AU - Barnes,P J, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 252 EP - 4 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 133 IS - 2 N2 - In the bronchi of asthmatic subjects many bronchoconstrictor mediators and neurotransmitters might be released together, and therefore, potential interactions might occur that could be important in airway hyperreactivity. We have studied the effect of inhaled methacholine, bradykinin, and prostaglandin D2 (PGD2) on bronchial reactivity to inhaled histamine in 6 mild asthmatic subjects, 22 to 36 yr of age. All of the test spasmogens were given at equivalent bronchoconstricting concentrations. Simultaneous dosing with PGD2 caused a significant increase in reactivity to histamine, mean dose of histamine causing a 35% fall in specific airway conductance being 0.72 mumol before, and 0.32 mumol with, PGD2; (p less than 0.01). This was not seen with histamine itself, methacholine, or bradykinin. Prostaglandin D2 caused a similar increase in bronchial reactivity to inhaled methacholine, suggesting a postreceptor potentiation of airway smooth muscle contractility. This positive interaction between inflammatory mediators known to be released in asthma has important implications for understanding bronchial hyperreactivity. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/3511806/Prostaglandin_D2_potentiates_airway_responsiveness_to_histamine_and_methacholine_ L2 - https://www.atsjournals.org/doi/10.1164/arrd.1986.133.2.252?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -