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Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study.
Skin Appendage Disord. 2022 Jan; 8(1):24-30.SA

Abstract

INTRODUCTION

Scalp biopsy is a standard method for the definitive diagnosis of alopecia. The hair count parameters of each scalp area remain unclear. This study aimed to determine hair count values at different scalp locations from histopathology and to establish reference values for each part of the scalp.

METHODS

We obtained biopsy specimens from the frontal, vertex, temporoparietal, and occipital areas of the scalps of normal deceased subjects. All specimens were evaluated for the number of follicular units, hair counts, hair types, and stages of the hair cycle.

RESULTS

In total, 240 specimens were collected from 60 cadavers. Across all scalp sites, the temporoparietal area showed the lowest mean hair count, number of follicular units, terminal and vellus hairs, and terminal-to-vellus hair ratio. The average anagen-to-telogen hair ratio was comparable across all scalp sites. This study did not observe a significant association of hair parameters with gender differences or increasing age in all scalp areas.

CONCLUSIONS

The present study revealed the diversity of the hair index among different scalp areas and suggested that normal hair count values should be separately standardized on each scalp region. Our findings may provide useful reference values for the histopathological evaluation of hair disorders in Asians.

Links

Authors+Show Affiliations

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Pakornphadungsit K

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Department of Pathology, Forensic Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35118125

Citation

Rutnin, Suthinee, et al. "Variation of Hair Follicle Counts Among Different Scalp Areas: a Quantitative Histopathological Study." Skin Appendage Disorders, vol. 8, no. 1, 2022, pp. 24-30.

Rutnin S, Chanprapaph K, Pakornphadungsit K, et al. Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study. Skin Appendage Disord. 2022;8(1):24-30.

Rutnin, S., Chanprapaph, K., Pakornphadungsit, K., Leerunyakul, K., Visessiri, Y., Srisont, S., & Suchonwanit, P. (2022). Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study. Skin Appendage Disorders, 8(1), 24-30. https://doi.org/10.1159/000518434

Rutnin S, et al. Variation of Hair Follicle Counts Among Different Scalp Areas: a Quantitative Histopathological Study. Skin Appendage Disord. 2022;8(1):24-30. PubMed PMID: 35118125.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study. AU - Rutnin,Suthinee, AU - Chanprapaph,Kumutnart, AU - Pakornphadungsit,Kallapan, AU - Leerunyakul,Kanchana, AU - Visessiri,Yingluck, AU - Srisont,Smith, AU - Suchonwanit,Poonkiat, Y1 - 2021/09/01/ PY - 2021/06/14/received PY - 2021/07/12/accepted PY - 2022/2/4/entrez PY - 2022/2/5/pubmed PY - 2022/2/5/medline KW - Alopecia KW - Biopsy KW - Hair loss KW - Horizontal section KW - Transverse section SP - 24 EP - 30 JF - Skin appendage disorders JO - Skin Appendage Disord VL - 8 IS - 1 N2 - INTRODUCTION: Scalp biopsy is a standard method for the definitive diagnosis of alopecia. The hair count parameters of each scalp area remain unclear. This study aimed to determine hair count values at different scalp locations from histopathology and to establish reference values for each part of the scalp. METHODS: We obtained biopsy specimens from the frontal, vertex, temporoparietal, and occipital areas of the scalps of normal deceased subjects. All specimens were evaluated for the number of follicular units, hair counts, hair types, and stages of the hair cycle. RESULTS: In total, 240 specimens were collected from 60 cadavers. Across all scalp sites, the temporoparietal area showed the lowest mean hair count, number of follicular units, terminal and vellus hairs, and terminal-to-vellus hair ratio. The average anagen-to-telogen hair ratio was comparable across all scalp sites. This study did not observe a significant association of hair parameters with gender differences or increasing age in all scalp areas. CONCLUSIONS: The present study revealed the diversity of the hair index among different scalp areas and suggested that normal hair count values should be separately standardized on each scalp region. Our findings may provide useful reference values for the histopathological evaluation of hair disorders in Asians. SN - 2296-9195 UR - https://www.unboundmedicine.com/medline/citation/35118125/Variation_of_Hair_Follicle_Counts_among_Different_Scalp_Areas:_A_Quantitative_Histopathological_Study_ DB - PRIME DP - Unbound Medicine ER -