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Biologic therapies associated with development of palmoplantar pustulosis and palmoplantar pustular psoriasis: a systematic review.
Int J Dermatol. 2023 Jan; 62(1):12-21.IJ

Abstract

BACKGROUND

Palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) are chronic inflammatory skin conditions characterized by eruptions of sterile pustules on the palms and/or soles. Biologic use has been associated with PPP and PPPP development in the literature.

OBJECTIVES

To identify PPP and PPPP associated with biologics and summarize reported treatments and outcomes.

METHODS

We systematically searched in MEDLINE and Embase for articles that reported PPP or PPPP during biologic treatment. After a full-text review, 53 studies were included for analysis.

RESULTS

We identified 155 patients with PPP/PPPP onset during biologic treatment, with a mean age of 44.1 years and a female preponderance (71.6%). The most frequently reported biologics were adalimumab (43.9%) and infliximab (33.3%). IL-17 inhibitors, secukinumab (7.6%) and brodalumab (1.5%), were reported only in association with PPPP. Overall, 58.8% of patients had complete remission (CR) in 3.6 months and 23.5% had partial remission (PR) in 3.7 months. The most common treatments that led to CR were topical corticosteroids (n = 16) and biologic switching (n = 8).

CONCLUSIONS

Clinicians should anticipate PPP or PPPP as potential drug reactions to biologics such as adalimumab and infliximab. Large-scale studies are required to confirm our findings and further explore the pathogenesis for biologic-associated PPP and PPPP.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lu JD
Faculty of Medicine, Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada.
Lytvyn Y
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Mufti A
Department of Dermatology, University of Toronto, Toronto, Ontario, Canada.
Zaaroura H
Department of Dermatology, University of Toronto, Toronto, Ontario, Canada.
Sachdeva M
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kwan S
Department of Dermatology, University of Toronto, Toronto, Ontario, Canada.
Abduelmula A
Faculty of Medicine, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Kim P
Faculty of Medicine, Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada.
Yeung J
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Department of Dermatology, University of Toronto, Toronto, Ontario, Canada. Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Women's College Hospital, Toronto, Ontario, Canada. Probity Medical Research Inc., Waterloo, Ontario, Canada.

MeSH

HumansFemaleAdultInfliximabAdalimumabPsoriasisExanthemaChronic DiseaseBiological TherapySkin Diseases, VesiculobullousAcute DiseaseBiological Products

Pub Type(s)

Systematic Review
Journal Article
Review

Language

eng

PubMed ID

35128653

Citation

Lu, Justin D., et al. "Biologic Therapies Associated With Development of Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis: a Systematic Review." International Journal of Dermatology, vol. 62, no. 1, 2023, pp. 12-21.
Lu JD, Lytvyn Y, Mufti A, et al. Biologic therapies associated with development of palmoplantar pustulosis and palmoplantar pustular psoriasis: a systematic review. Int J Dermatol. 2023;62(1):12-21.
Lu, J. D., Lytvyn, Y., Mufti, A., Zaaroura, H., Sachdeva, M., Kwan, S., Abduelmula, A., Kim, P., & Yeung, J. (2023). Biologic therapies associated with development of palmoplantar pustulosis and palmoplantar pustular psoriasis: a systematic review. International Journal of Dermatology, 62(1), 12-21. https://doi.org/10.1111/ijd.16064
Lu JD, et al. Biologic Therapies Associated With Development of Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis: a Systematic Review. Int J Dermatol. 2023;62(1):12-21. PubMed PMID: 35128653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biologic therapies associated with development of palmoplantar pustulosis and palmoplantar pustular psoriasis: a systematic review. AU - Lu,Justin D, AU - Lytvyn,Yuliya, AU - Mufti,Asfandyar, AU - Zaaroura,Hiba, AU - Sachdeva,Muskaan, AU - Kwan,Sarah, AU - Abduelmula,Abrahim, AU - Kim,Patrick, AU - Yeung,Jensen, Y1 - 2022/02/06/ PY - 2021/08/09/received PY - 2021/12/30/accepted PY - 2022/2/8/pubmed PY - 2022/2/8/medline PY - 2022/2/7/entrez SP - 12 EP - 21 JF - International journal of dermatology JO - Int J Dermatol VL - 62 IS - 1 N2 - BACKGROUND: Palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) are chronic inflammatory skin conditions characterized by eruptions of sterile pustules on the palms and/or soles. Biologic use has been associated with PPP and PPPP development in the literature. OBJECTIVES: To identify PPP and PPPP associated with biologics and summarize reported treatments and outcomes. METHODS: We systematically searched in MEDLINE and Embase for articles that reported PPP or PPPP during biologic treatment. After a full-text review, 53 studies were included for analysis. RESULTS: We identified 155 patients with PPP/PPPP onset during biologic treatment, with a mean age of 44.1 years and a female preponderance (71.6%). The most frequently reported biologics were adalimumab (43.9%) and infliximab (33.3%). IL-17 inhibitors, secukinumab (7.6%) and brodalumab (1.5%), were reported only in association with PPPP. Overall, 58.8% of patients had complete remission (CR) in 3.6 months and 23.5% had partial remission (PR) in 3.7 months. The most common treatments that led to CR were topical corticosteroids (n = 16) and biologic switching (n = 8). CONCLUSIONS: Clinicians should anticipate PPP or PPPP as potential drug reactions to biologics such as adalimumab and infliximab. Large-scale studies are required to confirm our findings and further explore the pathogenesis for biologic-associated PPP and PPPP. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/35128653/Biologic_therapies_associated_with_development_of_palmoplantar_pustulosis_and_palmoplantar_pustular_psoriasis:_a_systematic_review_ DB - PRIME DP - Unbound Medicine ER -