Tags

Type your tag names separated by a space and hit enter

In vitro studies of antidermatophytic activity of juliflorine and its screening as carcinogen in Salmonella/microsome test system.
Arzneimittelforschung. 1986; 36(1):17-9.A

Abstract

Juliflorine, an alkaloid from Prosopis juliflora, was tested for its antifungal activity against the freshly isolated cultures of dermatophytic fungi and its inhibitory effect was compared with that of griseofulvin. The results indicated that the minimum inhibitory concentration (MIC) of juliflorine against Trichophyton rubrum, Trichophyton violaceum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton megninii, Trichophyton gallinae, Microsporum canis, Microsporum nanum, Microsporum ferrugineum and Epidermophyton floccosum was 1.5 micrograms/ml, whereas that of griseofulvin was 0.1-0.5 microgram/ml. MIC of juliflorine for Candida albicans was 0.05 mg/ml. The alkaloid was also subjected to screening for carcinogenicity in the Ames test (salmonella/microsome test system). The results indicated that the compound in the recommended concentrations did not exhibit positive mutagenic reaction, as compared to a strong positive reaction by ethyl methane sulfonate based on his- ----his+ revertants.

Authors

Khursheed AK
No affiliation info available
Arshad HF
No affiliation info available
Viqaruddin A
No affiliation info available
Sabiha Q
No affiliation info available
Sheikh AR
No affiliation info available
Tahir SH
No affiliation info available

MeSH

AlkaloidsAntifungal AgentsArthrodermataceaeCandida albicansCarcinogensGriseofulvinMicrosporumMutagenicity TestsNystatinTrichophyton

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3513775

Citation

Khursheed, A K., et al. "In Vitro Studies of Antidermatophytic Activity of Juliflorine and Its Screening as Carcinogen in Salmonella/microsome Test System." Arzneimittel-Forschung, vol. 36, no. 1, 1986, pp. 17-9.
Khursheed AK, Arshad HF, Viqaruddin A, et al. In vitro studies of antidermatophytic activity of juliflorine and its screening as carcinogen in Salmonella/microsome test system. Arzneimittelforschung. 1986;36(1):17-9.
Khursheed, A. K., Arshad, H. F., Viqaruddin, A., Sabiha, Q., Sheikh, A. R., & Tahir, S. H. (1986). In vitro studies of antidermatophytic activity of juliflorine and its screening as carcinogen in Salmonella/microsome test system. Arzneimittel-Forschung, 36(1), 17-9.
Khursheed AK, et al. In Vitro Studies of Antidermatophytic Activity of Juliflorine and Its Screening as Carcinogen in Salmonella/microsome Test System. Arzneimittelforschung. 1986;36(1):17-9. PubMed PMID: 3513775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro studies of antidermatophytic activity of juliflorine and its screening as carcinogen in Salmonella/microsome test system. AU - Khursheed,A K, AU - Arshad,H F, AU - Viqaruddin,A, AU - Sabiha,Q, AU - Sheikh,A R, AU - Tahir,S H, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 17 EP - 9 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 36 IS - 1 N2 - Juliflorine, an alkaloid from Prosopis juliflora, was tested for its antifungal activity against the freshly isolated cultures of dermatophytic fungi and its inhibitory effect was compared with that of griseofulvin. The results indicated that the minimum inhibitory concentration (MIC) of juliflorine against Trichophyton rubrum, Trichophyton violaceum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton megninii, Trichophyton gallinae, Microsporum canis, Microsporum nanum, Microsporum ferrugineum and Epidermophyton floccosum was 1.5 micrograms/ml, whereas that of griseofulvin was 0.1-0.5 microgram/ml. MIC of juliflorine for Candida albicans was 0.05 mg/ml. The alkaloid was also subjected to screening for carcinogenicity in the Ames test (salmonella/microsome test system). The results indicated that the compound in the recommended concentrations did not exhibit positive mutagenic reaction, as compared to a strong positive reaction by ethyl methane sulfonate based on his- ----his+ revertants. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3513775/In_vitro_studies_of_antidermatophytic_activity_of_juliflorine_and_its_screening_as_carcinogen_in_Salmonella/microsome_test_system_ DB - PRIME DP - Unbound Medicine ER -