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Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review.
J Neurol Sci. 2022 Mar 15; 434:120166.JN

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative diseases, both without prevention or cure. The Mediterranean diet (MeDi) may be neuroprotective by modulating gut microbiota. We aimed to assess the effects of adherence to MeDi on the gut microbiota in relation to AD or PD risk. A search from inception to November 2020 was conducted in PubMed, CINAHL, EMBASE, Web of Science, Global Health, Biological Abstracts, and Grey Literature Report databases. Two searches were conducted: 1) (MeDi or Microbiota) and (PD or AD) and 2) MeDi and microbiota. Inclusion criteria for papers were specified prior to review. Of 4672 studies identified, 64 were eligible for inclusion. These studies were divided into five groups: MeDi and AD risk (n = 4), MeDi and PD risk (n = 2), MeDi and microbial composition or metabolomics (n = 21), AD and microbial composition or metabolomics (n = 7), and PD and microbial composition or metabolomics (n = 30). Adherence to the MeDi was associated with a lower risk of AD and PD development. Eight genera and two species of bacteria had an inverse relationship with MeDi and AD, and one family, eight genera and three species of bacteria had an inverse relationship with MeDi and PD. More studies are needed to investigate if MeDi, gut microbiota, and neurodegeneration are causally related.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America.

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America.

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America.

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America.

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America.

Office of Academic Affairs and Provost, Tulane University, New Orleans, LA 70112, United States of America.

Rudolph Matas Library of the Health Sciences, Tulane University, New Orleans, LA 70112, United States of America.

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America.

Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America. Electronic address: dmaraganore@tulane.edu.

MeSH

Alzheimer DiseaseDiet, MediterraneanGastrointestinal MicrobiomeHumansParkinson DiseaseRisk

Pub Type(s)

Journal Article

Review

Systematic Review

Language

eng

PubMed ID

35144237

Citation

Solch, Rebecca J., et al. "Mediterranean Diet Adherence, Gut Microbiota, and Alzheimer's or Parkinson's Disease Risk: a Systematic Review." Journal of the Neurological Sciences, vol. 434, 2022, p. 120166.

Solch RJ, Aigbogun JO, Voyiadjis AG, et al. Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review. J Neurol Sci. 2022;434:120166.

Solch, R. J., Aigbogun, J. O., Voyiadjis, A. G., Talkington, G. M., Darensbourg, R. M., O'Connell, S., Pickett, K. M., Perez, S. R., & Maraganore, D. M. (2022). Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review. Journal of the Neurological Sciences, 434, 120166. https://doi.org/10.1016/j.jns.2022.120166

Solch RJ, et al. Mediterranean Diet Adherence, Gut Microbiota, and Alzheimer's or Parkinson's Disease Risk: a Systematic Review. J Neurol Sci. 2022 Mar 15;434:120166. PubMed PMID: 35144237.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review. AU - Solch,Rebecca J, AU - Aigbogun,Julia O, AU - Voyiadjis,Andrew G, AU - Talkington,Grant M, AU - Darensbourg,Revonda M, AU - O'Connell,Samantha, AU - Pickett,Keith M, AU - Perez,Sarah R, AU - Maraganore,Demetrius M, Y1 - 2022/01/26/ PY - 2021/10/05/received PY - 2022/01/14/revised PY - 2022/01/18/accepted PY - 2022/2/11/pubmed PY - 2022/4/14/medline PY - 2022/2/10/entrez KW - Alzheimer's disease KW - Mediterranean diet KW - Microbiota KW - Parkinson's disease SP - 120166 EP - 120166 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 434 N2 - Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative diseases, both without prevention or cure. The Mediterranean diet (MeDi) may be neuroprotective by modulating gut microbiota. We aimed to assess the effects of adherence to MeDi on the gut microbiota in relation to AD or PD risk. A search from inception to November 2020 was conducted in PubMed, CINAHL, EMBASE, Web of Science, Global Health, Biological Abstracts, and Grey Literature Report databases. Two searches were conducted: 1) (MeDi or Microbiota) and (PD or AD) and 2) MeDi and microbiota. Inclusion criteria for papers were specified prior to review. Of 4672 studies identified, 64 were eligible for inclusion. These studies were divided into five groups: MeDi and AD risk (n = 4), MeDi and PD risk (n = 2), MeDi and microbial composition or metabolomics (n = 21), AD and microbial composition or metabolomics (n = 7), and PD and microbial composition or metabolomics (n = 30). Adherence to the MeDi was associated with a lower risk of AD and PD development. Eight genera and two species of bacteria had an inverse relationship with MeDi and AD, and one family, eight genera and three species of bacteria had an inverse relationship with MeDi and PD. More studies are needed to investigate if MeDi, gut microbiota, and neurodegeneration are causally related. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/35144237/Mediterranean_diet_adherence_gut_microbiota_and_Alzheimer's_or_Parkinson's_disease_risk:_A_systematic_review_ DB - PRIME DP - Unbound Medicine ER -