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Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press.
Int J Pharm. 2022 Mar 25; 616:121562.IJ

Abstract

Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the effect of lubricant blending time and PS of forced feeders on the tensile strength of lubricated microcrystalline cellulose (MCC) and lactose tablets. Magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and stearic acid (SA) were used as lubricants. Tablets were produced on a compaction simulator and a rotary tablet press to investigate lubricant sensitivity during upscaling. Lubricant sensitivity was found higher for MCC compared to lactose which was attributed to the higher plasticity of MCC. The reduction in tensile strength upon lubricant addition followed the order: MgSt > SSF > SA; which could be linked to particle size, specific surface area and particle shape of the lubricants. Although differences in tensile strength were observed between the lubricant types, comparable ejection forces were obtained. The impact of PS on tensile strength was higher compared to lubricant blending time for both tableting machines. A good correlation of tensile strength and lubricant sensitivity between the compaction simulator and rotary tablet press was observed based on the calculation of paddle passes (NPP).

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Publisher Full Text (DOI)

Authors+Show Affiliations

de Backere C
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
De Beer T
Laboratory of Pharmaceutical Process Analytical Technology, Department of Pharmaceutical Analysis, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Vervaet C
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Vanhoorne V
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address: valerie.vanhoorne@ugent.be.

MeSH

ExcipientsLactoseLubricantsLubricationStearic AcidsTabletsTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35150846

Citation

de Backere, Cedrine, et al. "Effect of Feed Frame On Lubricant Sensitivity During Upscaling From a Compaction Simulator to a Rotary Tablet Press." International Journal of Pharmaceutics, vol. 616, 2022, p. 121562.
de Backere C, De Beer T, Vervaet C, et al. Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press. Int J Pharm. 2022;616:121562.
de Backere, C., De Beer, T., Vervaet, C., & Vanhoorne, V. (2022). Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press. International Journal of Pharmaceutics, 616, 121562. https://doi.org/10.1016/j.ijpharm.2022.121562
de Backere C, et al. Effect of Feed Frame On Lubricant Sensitivity During Upscaling From a Compaction Simulator to a Rotary Tablet Press. Int J Pharm. 2022 Mar 25;616:121562. PubMed PMID: 35150846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press. AU - de Backere,Cedrine, AU - De Beer,Thomas, AU - Vervaet,Chris, AU - Vanhoorne,Valérie, Y1 - 2022/02/10/ PY - 2021/12/09/received PY - 2022/01/26/revised PY - 2022/02/05/accepted PY - 2022/2/13/pubmed PY - 2022/3/15/medline PY - 2022/2/12/entrez KW - Compaction simulator KW - Direct compression KW - Internal lubrication KW - Lubricant sensitivity KW - Powder compaction KW - Upscaling SP - 121562 EP - 121562 JF - International journal of pharmaceutics JO - Int J Pharm VL - 616 N2 - Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the effect of lubricant blending time and PS of forced feeders on the tensile strength of lubricated microcrystalline cellulose (MCC) and lactose tablets. Magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and stearic acid (SA) were used as lubricants. Tablets were produced on a compaction simulator and a rotary tablet press to investigate lubricant sensitivity during upscaling. Lubricant sensitivity was found higher for MCC compared to lactose which was attributed to the higher plasticity of MCC. The reduction in tensile strength upon lubricant addition followed the order: MgSt > SSF > SA; which could be linked to particle size, specific surface area and particle shape of the lubricants. Although differences in tensile strength were observed between the lubricant types, comparable ejection forces were obtained. The impact of PS on tensile strength was higher compared to lubricant blending time for both tableting machines. A good correlation of tensile strength and lubricant sensitivity between the compaction simulator and rotary tablet press was observed based on the calculation of paddle passes (NPP). SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/35150846/Effect_of_feed_frame_on_lubricant_sensitivity_during_upscaling_from_a_compaction_simulator_to_a_rotary_tablet_press_ DB - PRIME DP - Unbound Medicine ER -