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[Regularity of prescriptions for intermediate and advanced lung cancer based on latent structure combined with association rules].
Zhongguo Zhong Yao Za Zhi. 2022 Jan; 47(1):235-243.ZZ

Abstract

The present study explored the regularity of prescriptions for the treatment of intermediate and advanced lung cancer to provide references for clinical medication. CNKI, Wanfang, VIP, and CBM were searched for the research papers on the treatment of lung cancer by Chinese medicine published from database inception to May 31, 2021. The relevant information of qualified papers was extracted to establish a database. The Chinese medicines with frequency >3% underwent analysis of the latent structure and association rules by Lantern 5.0 and SPSS Molder 14.1, respectively, and the prescription regularity in the treatment of intermediate and advanced lung cancer was analyzed based on the frequency description. A total of 713 papers were included, involving 327 Chinese medicines with a cumulative frequency of 12 794 and 106 prescriptions with a cumulative frequency of 824. The commonly used Chinese medicines were dominated by deficiency-tonifying, heat-clearing, phlegm-resolving, and cough/dyspnea-relieving drugs, such as Astragali Radix, Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix et Rhizoma, Ophiopogonis Radix, Poria, and Hedyotis Diffusa, which are cold, warm, and plain in nature and sweet, bitter, and pungent in flavor, and mainly act on lung, spleen, and stomach meridians. Commonly used prescriptions included Shashen Maidong Decoction, Liujunzi Decoction, and Baihe Gujin Decoction. The latent structure analysis revealed 32 latent variables and 65 hidden classes. Six comprehensive clustering models and 11 core prescriptions were obtained by professional knowledge inference. The common syndromes of intermediate and advanced lung cancer were inferred to be Qi and Yin deficiency in the lung, Qi deficiency in the lung and spleen, Yin deficiency in the liver and kidney, combined phlegm and stasis, phlegm-heat obstructing lung, and Qi stagnation and blood stasis. Forty-four strong associations were screened out by association rules analysis, including four pairwise strong associations(Polygonati Odorati Rhizoma→Ophiopogonis Radix, Polygonati Odorati Rhizoma→Glehniae Radix, Amomi Fructus→Atractylodis Macrocephalae Rhizoma, and Polygonati Rhizoma→Astragali Radix) and 40 triplet strong associations(such as Trichosanthis Radix+Glehniae Radix→Ophiopogonis Radix, Polygonati Odorati Rhizoma+Glehniae Radix→Ophiopogonis Radix, Trichosanthis Radix+Ophiopogonis Radix→Glehniae Radix, and Scutellariae Barbatae Herba+Codonopsis Radix→Hedyotis Diffusa). In the treatment of intermediate and advanced lung cancer, Qi-replenishing and Yin-nourishing drugs are mainly employed, assisted with cancer-resisting, toxin-removing, spleen-invigorating, phlegm/stasis-resolving, and blood-activating drugs based on syndrome differentiation. The roots were treated following the principles of tonifying lungs and replenishing the spleen, and symptoms following the principles of removing the toxin, dispelling stasis, and resolving phlegm.

Authors+Show Affiliations

Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine Zhengzhou 450000, China.the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450003, China.Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine Zhengzhou 450000, China.Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine Zhengzhou 450000, China.Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine Zhengzhou 450000, China.Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine Zhengzhou 450000, China the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450003, China.Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine Zhengzhou 450000, China the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450003, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

35178930

Citation

Zhang, Dong, et al. "[Regularity of Prescriptions for Intermediate and Advanced Lung Cancer Based On Latent Structure Combined With Association Rules]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 47, no. 1, 2022, pp. 235-243.
Zhang D, Feng ZZ, Wang L, et al. [Regularity of prescriptions for intermediate and advanced lung cancer based on latent structure combined with association rules]. Zhongguo Zhong Yao Za Zhi. 2022;47(1):235-243.
Zhang, D., Feng, Z. Z., Wang, L., Guo, W., Liu, W. R., Zhang, H. L., & Li, J. S. (2022). [Regularity of prescriptions for intermediate and advanced lung cancer based on latent structure combined with association rules]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 47(1), 235-243. https://doi.org/10.19540/j.cnki.cjcmm.20210722.501
Zhang D, et al. [Regularity of Prescriptions for Intermediate and Advanced Lung Cancer Based On Latent Structure Combined With Association Rules]. Zhongguo Zhong Yao Za Zhi. 2022;47(1):235-243. PubMed PMID: 35178930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Regularity of prescriptions for intermediate and advanced lung cancer based on latent structure combined with association rules]. AU - Zhang,Dong, AU - Feng,Zhen-Zhen, AU - Wang,Lu, AU - Guo,Wen, AU - Liu,Wen-Rui, AU - Zhang,Hai-Long, AU - Li,Jian-Sheng, PY - 2022/2/18/entrez PY - 2022/2/19/pubmed PY - 2022/2/22/medline KW - association rule KW - intermediate and advanced lung cancer KW - latent structure KW - traditional Chinese medicine SP - 235 EP - 243 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 47 IS - 1 N2 - The present study explored the regularity of prescriptions for the treatment of intermediate and advanced lung cancer to provide references for clinical medication. CNKI, Wanfang, VIP, and CBM were searched for the research papers on the treatment of lung cancer by Chinese medicine published from database inception to May 31, 2021. The relevant information of qualified papers was extracted to establish a database. The Chinese medicines with frequency >3% underwent analysis of the latent structure and association rules by Lantern 5.0 and SPSS Molder 14.1, respectively, and the prescription regularity in the treatment of intermediate and advanced lung cancer was analyzed based on the frequency description. A total of 713 papers were included, involving 327 Chinese medicines with a cumulative frequency of 12 794 and 106 prescriptions with a cumulative frequency of 824. The commonly used Chinese medicines were dominated by deficiency-tonifying, heat-clearing, phlegm-resolving, and cough/dyspnea-relieving drugs, such as Astragali Radix, Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix et Rhizoma, Ophiopogonis Radix, Poria, and Hedyotis Diffusa, which are cold, warm, and plain in nature and sweet, bitter, and pungent in flavor, and mainly act on lung, spleen, and stomach meridians. Commonly used prescriptions included Shashen Maidong Decoction, Liujunzi Decoction, and Baihe Gujin Decoction. The latent structure analysis revealed 32 latent variables and 65 hidden classes. Six comprehensive clustering models and 11 core prescriptions were obtained by professional knowledge inference. The common syndromes of intermediate and advanced lung cancer were inferred to be Qi and Yin deficiency in the lung, Qi deficiency in the lung and spleen, Yin deficiency in the liver and kidney, combined phlegm and stasis, phlegm-heat obstructing lung, and Qi stagnation and blood stasis. Forty-four strong associations were screened out by association rules analysis, including four pairwise strong associations(Polygonati Odorati Rhizoma→Ophiopogonis Radix, Polygonati Odorati Rhizoma→Glehniae Radix, Amomi Fructus→Atractylodis Macrocephalae Rhizoma, and Polygonati Rhizoma→Astragali Radix) and 40 triplet strong associations(such as Trichosanthis Radix+Glehniae Radix→Ophiopogonis Radix, Polygonati Odorati Rhizoma+Glehniae Radix→Ophiopogonis Radix, Trichosanthis Radix+Ophiopogonis Radix→Glehniae Radix, and Scutellariae Barbatae Herba+Codonopsis Radix→Hedyotis Diffusa). In the treatment of intermediate and advanced lung cancer, Qi-replenishing and Yin-nourishing drugs are mainly employed, assisted with cancer-resisting, toxin-removing, spleen-invigorating, phlegm/stasis-resolving, and blood-activating drugs based on syndrome differentiation. The roots were treated following the principles of tonifying lungs and replenishing the spleen, and symptoms following the principles of removing the toxin, dispelling stasis, and resolving phlegm. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/35178930/[Regularity_of_prescriptions_for_intermediate_and_advanced_lung_cancer_based_on_latent_structure_combined_with_association_rules]_ L2 - https://www.diseaseinfosearch.org/result/4334 DB - PRIME DP - Unbound Medicine ER -