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Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses.
Res Vet Sci. 1986 Mar; 40(2):152-6.RV

Abstract

The efficacy of three agents which alter the metabolism of arachidonic acid was investigated in normal, conscious horses. A dose response evaluation was made of flunixin meglumine and phenylbutazone, two cyclo-oxygenase inhibitors, and of a selective thromboxane synthetase inhibitor, UK-38,485. Radioimmunoassay of thromboxane B2 (TxB2) and 6-keto prostaglandin F1 alpha (PGF1 alpha) was used to assess the concentrations of thromboxane A2 (TxA2) and prostacyclin (PGI2) respectively, in serum. Flunixin was the most potent inhibitor of serum TxB2 and 6-keto PGF1 alpha production. UK-38,485 also decreased serum TxB2 generation while significantly increasing serum 6-keto PGF1 alpha levels, thus confirming its selectivity as a thromboxane synthetase inhibitor.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3517992

Citation

Hardee, M M., et al. "Effects of Flunixin Meglumine, Phenylbutazone and a Selective Thromboxane Synthetase Inhibitor (UK-38,485) On Thromboxane and Prostacyclin Production in Healthy Horses." Research in Veterinary Science, vol. 40, no. 2, 1986, pp. 152-6.
Hardee MM, Moore JN, Hardee GE. Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses. Res Vet Sci. 1986;40(2):152-6.
Hardee, M. M., Moore, J. N., & Hardee, G. E. (1986). Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses. Research in Veterinary Science, 40(2), 152-6.
Hardee MM, Moore JN, Hardee GE. Effects of Flunixin Meglumine, Phenylbutazone and a Selective Thromboxane Synthetase Inhibitor (UK-38,485) On Thromboxane and Prostacyclin Production in Healthy Horses. Res Vet Sci. 1986;40(2):152-6. PubMed PMID: 3517992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses. AU - Hardee,M M, AU - Moore,J N, AU - Hardee,G E, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 152 EP - 6 JF - Research in veterinary science JO - Res Vet Sci VL - 40 IS - 2 N2 - The efficacy of three agents which alter the metabolism of arachidonic acid was investigated in normal, conscious horses. A dose response evaluation was made of flunixin meglumine and phenylbutazone, two cyclo-oxygenase inhibitors, and of a selective thromboxane synthetase inhibitor, UK-38,485. Radioimmunoassay of thromboxane B2 (TxB2) and 6-keto prostaglandin F1 alpha (PGF1 alpha) was used to assess the concentrations of thromboxane A2 (TxA2) and prostacyclin (PGI2) respectively, in serum. Flunixin was the most potent inhibitor of serum TxB2 and 6-keto PGF1 alpha production. UK-38,485 also decreased serum TxB2 generation while significantly increasing serum 6-keto PGF1 alpha levels, thus confirming its selectivity as a thromboxane synthetase inhibitor. SN - 0034-5288 UR - https://www.unboundmedicine.com/medline/citation/3517992/Effects_of_flunixin_meglumine_phenylbutazone_and_a_selective_thromboxane_synthetase_inhibitor__UK_38485__on_thromboxane_and_prostacyclin_production_in_healthy_horses_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -