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Effect of hydration on plasma vasopressin, renin, and aldosterone responses to head-up tilt.
Aviat Space Environ Med. 1986 May; 57(5):420-5.AS

Abstract

If plasma vasopressin (PVP), plasma renin (PRA), and plasma aldosterone (PA) responses to change in posture are mediated only by alterations in intrathoracic baroreceptor activity, hydration status should have minimal influence on these responses. To test this hypothesis, six male subjects underwent 45 min of 70 degree head-up tilt (HUT) following 26 h dehydration, and again, 105 min later, following rehydration. Compared with preceding supine hydrated control values, PVP, PRA, and PA increased (p less than 0.001) during dehydrated HUT, but only PVP and PRA increased during rehydrated HUT (p less than 0.001). The dissociation during rehydrated HUT of PRA and PA may have been related more to the reduction (p less than 0.001) in plasma potassium concentration than to the accompanying decrease (p less than 0.001) in plasma osmolality and sodium concentration. Although increases in PVP and PRA during HUT were attenuated (p less than 0.01) following rehydration, this attenuation was associated with the absence of symptoms of overt hypotension following rehydration. However, since rehydration did not abolish the increases in PVP and PRA induced by HUT, it is concluded that the present observations support the concept of intrathoracic baroreceptor involvement in the regulation of vasopressin secretion and renin release.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3518690

Citation

Harrison, M H., et al. "Effect of Hydration On Plasma Vasopressin, Renin, and Aldosterone Responses to Head-up Tilt." Aviation, Space, and Environmental Medicine, vol. 57, no. 5, 1986, pp. 420-5.
Harrison MH, Geelen G, Keil LC, et al. Effect of hydration on plasma vasopressin, renin, and aldosterone responses to head-up tilt. Aviat Space Environ Med. 1986;57(5):420-5.
Harrison, M. H., Geelen, G., Keil, L. C., Wade, C. A., Hill, L. C., Kravik, S. E., & Greenleaf, J. E. (1986). Effect of hydration on plasma vasopressin, renin, and aldosterone responses to head-up tilt. Aviation, Space, and Environmental Medicine, 57(5), 420-5.
Harrison MH, et al. Effect of Hydration On Plasma Vasopressin, Renin, and Aldosterone Responses to Head-up Tilt. Aviat Space Environ Med. 1986;57(5):420-5. PubMed PMID: 3518690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hydration on plasma vasopressin, renin, and aldosterone responses to head-up tilt. AU - Harrison,M H, AU - Geelen,G, AU - Keil,L C, AU - Wade,C A, AU - Hill,L C, AU - Kravik,S E, AU - Greenleaf,J E, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 420 EP - 5 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 57 IS - 5 N2 - If plasma vasopressin (PVP), plasma renin (PRA), and plasma aldosterone (PA) responses to change in posture are mediated only by alterations in intrathoracic baroreceptor activity, hydration status should have minimal influence on these responses. To test this hypothesis, six male subjects underwent 45 min of 70 degree head-up tilt (HUT) following 26 h dehydration, and again, 105 min later, following rehydration. Compared with preceding supine hydrated control values, PVP, PRA, and PA increased (p less than 0.001) during dehydrated HUT, but only PVP and PRA increased during rehydrated HUT (p less than 0.001). The dissociation during rehydrated HUT of PRA and PA may have been related more to the reduction (p less than 0.001) in plasma potassium concentration than to the accompanying decrease (p less than 0.001) in plasma osmolality and sodium concentration. Although increases in PVP and PRA during HUT were attenuated (p less than 0.01) following rehydration, this attenuation was associated with the absence of symptoms of overt hypotension following rehydration. However, since rehydration did not abolish the increases in PVP and PRA induced by HUT, it is concluded that the present observations support the concept of intrathoracic baroreceptor involvement in the regulation of vasopressin secretion and renin release. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/3518690/Effect_of_hydration_on_plasma_vasopressin_renin_and_aldosterone_responses_to_head_up_tilt_ L2 - https://medlineplus.gov/dehydration.html DB - PRIME DP - Unbound Medicine ER -