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The adverse effects of hormonal therapy.
Cardiol Clin. 1986 Feb; 4(1):145-52.CC

Abstract

Estrogen therapy must be cycled with progestin therapy in women with intact uteri in order to prevent uterine cancer. However, these women cannot be expected to benefit (with regard to cardiovascular disease) from any estrogen-induced changes in the lipoprotein profile, as progestins will either negate or overwhelm any estrogen effects. However, such women will definitely benefit from estrogen's effects with regard to menopausal symptoms and bone loss. These clearly beneficial effects of estrogen-progestin therapy are not outweighed by any known risks. However, in women without uteri (approximately 30 per cent of women), unopposed estrogen therapy in the menopause may protect against cardiovascular disease, as well as have beneficial effects on bone metabolism and menopausal symptoms. In this special case, the beneficial effects of unopposed estrogen therapy clearly outweigh any known risk.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3518931

Citation

Bush, T L.. "The Adverse Effects of Hormonal Therapy." Cardiology Clinics, vol. 4, no. 1, 1986, pp. 145-52.
Bush TL. The adverse effects of hormonal therapy. Cardiol Clin. 1986;4(1):145-52.
Bush, T. L. (1986). The adverse effects of hormonal therapy. Cardiology Clinics, 4(1), 145-52.
Bush TL. The Adverse Effects of Hormonal Therapy. Cardiol Clin. 1986;4(1):145-52. PubMed PMID: 3518931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The adverse effects of hormonal therapy. A1 - Bush,T L, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez KW - Behavior KW - Biology KW - Cancer KW - Carbohydrate Metabolic Effects KW - Cardiovascular Effects KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Contraceptive Methods--beneficial effects KW - Contraceptive Methods--side effects KW - Contraceptive Methods--therapeutic use KW - Diseases KW - Embolism KW - Endocrine System KW - Endometrial Cancer KW - Estrogenic Substances, Conjugated KW - Estrogens KW - Family Planning KW - Glucose Metabolism Effects KW - Heart Diseases KW - Hormones KW - Hypertension KW - Lipid Metabolic Effects KW - Lipids KW - Literature Review KW - Medroxyprogesterone Acetate KW - Menopause KW - Metabolic Effects KW - Myocardial Infarction KW - Neoplasms KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose--beneficial effects KW - Oral Contraceptives, Low-dose--side effects KW - Oral Contraceptives, Low-dose--therapeutic use KW - Oral Contraceptives--beneficial effects KW - Oral Contraceptives--side effects KW - Oral Contraceptives--therapeutic use KW - Physiology KW - Reproduction KW - Smoking KW - Social Behavior KW - Thromboembolism KW - Vascular Diseases SP - 145 EP - 52 JF - Cardiology clinics JO - Cardiol Clin VL - 4 IS - 1 N2 - Estrogen therapy must be cycled with progestin therapy in women with intact uteri in order to prevent uterine cancer. However, these women cannot be expected to benefit (with regard to cardiovascular disease) from any estrogen-induced changes in the lipoprotein profile, as progestins will either negate or overwhelm any estrogen effects. However, such women will definitely benefit from estrogen's effects with regard to menopausal symptoms and bone loss. These clearly beneficial effects of estrogen-progestin therapy are not outweighed by any known risks. However, in women without uteri (approximately 30 per cent of women), unopposed estrogen therapy in the menopause may protect against cardiovascular disease, as well as have beneficial effects on bone metabolism and menopausal symptoms. In this special case, the beneficial effects of unopposed estrogen therapy clearly outweigh any known risk. SN - 0733-8651 UR - https://www.unboundmedicine.com/medline/citation/3518931/The_adverse_effects_of_hormonal_therapy_ DB - PRIME DP - Unbound Medicine ER -
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