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An ultrastructural study of the response of traumatized rabbit tibial nerve to epineurial infection with Mycobacterium leprae.
Int J Lepr Other Mycobact Dis. 1986 Mar; 54(1):79-83.IJ

Abstract

Crushed rabbit tibial nerves were inoculated with a suspension of living Mycobacterium leprae at and just distal to the site of nerve trauma. The resulting changes occurring over a period of time from 40 min to 72 hr post-inoculation were studied electron microscopically. Bacilli were seen in perineurial cells and in macrophages that had infiltrated the perineurium adjacent to epineurial deposits of M. leprae. It is suggested that trauma may weaken the perineurial barrier and facilitate the transperineurial passage of phagocytes, some of which may be laden with M. leprae, and may thus be a means whereby M. leprae enter the endoneurium of peripheral nerves.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3519806

Citation

Chandi, S M., and C J. Chacko. "An Ultrastructural Study of the Response of Traumatized Rabbit Tibial Nerve to Epineurial Infection With Mycobacterium Leprae." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 54, no. 1, 1986, pp. 79-83.
Chandi SM, Chacko CJ. An ultrastructural study of the response of traumatized rabbit tibial nerve to epineurial infection with Mycobacterium leprae. Int J Lepr Other Mycobact Dis. 1986;54(1):79-83.
Chandi, S. M., & Chacko, C. J. (1986). An ultrastructural study of the response of traumatized rabbit tibial nerve to epineurial infection with Mycobacterium leprae. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 54(1), 79-83.
Chandi SM, Chacko CJ. An Ultrastructural Study of the Response of Traumatized Rabbit Tibial Nerve to Epineurial Infection With Mycobacterium Leprae. Int J Lepr Other Mycobact Dis. 1986;54(1):79-83. PubMed PMID: 3519806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An ultrastructural study of the response of traumatized rabbit tibial nerve to epineurial infection with Mycobacterium leprae. AU - Chandi,S M, AU - Chacko,C J, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 79 EP - 83 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 54 IS - 1 N2 - Crushed rabbit tibial nerves were inoculated with a suspension of living Mycobacterium leprae at and just distal to the site of nerve trauma. The resulting changes occurring over a period of time from 40 min to 72 hr post-inoculation were studied electron microscopically. Bacilli were seen in perineurial cells and in macrophages that had infiltrated the perineurium adjacent to epineurial deposits of M. leprae. It is suggested that trauma may weaken the perineurial barrier and facilitate the transperineurial passage of phagocytes, some of which may be laden with M. leprae, and may thus be a means whereby M. leprae enter the endoneurium of peripheral nerves. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3519806/An_ultrastructural_study_of_the_response_of_traumatized_rabbit_tibial_nerve_to_epineurial_infection_with_Mycobacterium_leprae_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -