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Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin.
Dermatol Clin. 1986 Jul; 4(3):433-46.DC

Abstract

Cutaneous aging represents a complex situation in which at least two independent factors--innate aging and solar exposure--contribute to the development of degenerative changes in the dermis. The biochemical and ultrastructural evidence reviewed in this article indicates that reduced collagen deposition, as a result of diminished collagen biosynthesis and reduced proliferative capacity of the fibroblasts, could explain the development of dermal atrophy and would relate to poor wound healing in the elderly. At the same time, perturbations in the supramolecular organization of the elastic fiber network lead to alterations in the mechanical properties of the skin, as manifested by loose and sagging skin with reduced resilience and elasticity.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

3521988

Citation

Uitto, J. "Connective Tissue Biochemistry of the Aging Dermis. Age-related Alterations in Collagen and Elastin." Dermatologic Clinics, vol. 4, no. 3, 1986, pp. 433-46.
Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin. 1986;4(3):433-46.
Uitto, J. (1986). Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatologic Clinics, 4(3), 433-46.
Uitto J. Connective Tissue Biochemistry of the Aging Dermis. Age-related Alterations in Collagen and Elastin. Dermatol Clin. 1986;4(3):433-46. PubMed PMID: 3521988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. A1 - Uitto,J, PY - 1986/7/1/pubmed PY - 1986/7/1/medline PY - 1986/7/1/entrez SP - 433 EP - 46 JF - Dermatologic clinics JO - Dermatol Clin VL - 4 IS - 3 N2 - Cutaneous aging represents a complex situation in which at least two independent factors--innate aging and solar exposure--contribute to the development of degenerative changes in the dermis. The biochemical and ultrastructural evidence reviewed in this article indicates that reduced collagen deposition, as a result of diminished collagen biosynthesis and reduced proliferative capacity of the fibroblasts, could explain the development of dermal atrophy and would relate to poor wound healing in the elderly. At the same time, perturbations in the supramolecular organization of the elastic fiber network lead to alterations in the mechanical properties of the skin, as manifested by loose and sagging skin with reduced resilience and elasticity. SN - 0733-8635 UR - https://www.unboundmedicine.com/medline/citation/3521988/Connective_tissue_biochemistry_of_the_aging_dermis__Age_related_alterations_in_collagen_and_elastin_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -