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Red meat consumption and all-cause and cardiovascular mortality: results from the UK Biobank study.
Eur J Nutr. 2022 Aug; 61(5):2543-2553.EJ

Abstract

PURPOSE

To investigate the prospective associations between red meat consumption and all-cause and cardiovascular diseases (CVD) mortality, and to assess the modification effects of lifestyle and genetic risk factors.

METHODS

180,642 individuals free of CVD or cancer were enrolled from 2006 to 2010 and followed up to 2018 in the UK Biobank. Information on demographics, lifestyles, and medical history was collected through a baseline touchscreen questionnaire. The information on diet was collected through a single touchscreen food-frequency questionnaire. A total of ten single-nucleotide polymorphisms were used to calculate the genetic risk score (GRS) of trimethylamine N-oxide (TMAO), a gut microbiota metabolite from red meat. Adjusted Cox proportional hazard regression models were used to assess the association of red meat consumption with mortality.

RESULTS

We documented 3596 deaths [655 CVD deaths, 285 coronary heart disease (CHD) deaths, and 149 stroke deaths] during median 8.6 years of follow-up. Compared with the lowest red meat intake (< 1.5 times/week), the highest red meat intake (≥ 3.0 times/week) was associated with a 20%, 53%, and 101% elevated risk for CVD, CHD, and stroke mortality (P for trend = 0.04, 0.007, and 0.02, respectively), but not all-cause mortality. We found that the associations between red meat intake and mortality were not modified by dietary and lifestyle factors, as well as TMAO GRS. In addition, substitution analyses showed that a decrease in red meat consumption and an increase in the consumption of poultry or cereal was significantly associated with 9%-16% lower CVD or CHD mortality risk.

CONCLUSION

Our results indicated that red meat consumption was associated with higher risks of CVD, CHD, and stroke mortality, and the associations were not modified by lifestyle and genetic risk factors. Replacing red meat by poultry or cereal was related to lower risks of CVD and CHD mortality.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang M
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.
Ma H
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.
Song Q
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA. Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Zhou T
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.
Hu Y
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Heianza Y
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.
Manson JE
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Qi L
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA. lqi1@tulane.edu. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. lqi1@tulane.edu. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. lqi1@tulane.edu.

MeSH

AnimalsBiological Specimen BanksCardiovascular DiseasesCoronary DiseaseDietHumansMeatPoultryProspective StudiesRed MeatRisk FactorsStrokeUnited Kingdom

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35220441

Citation

Wang, Mengying, et al. "Red Meat Consumption and All-cause and Cardiovascular Mortality: Results From the UK Biobank Study." European Journal of Nutrition, vol. 61, no. 5, 2022, pp. 2543-2553.
Wang M, Ma H, Song Q, et al. Red meat consumption and all-cause and cardiovascular mortality: results from the UK Biobank study. Eur J Nutr. 2022;61(5):2543-2553.
Wang, M., Ma, H., Song, Q., Zhou, T., Hu, Y., Heianza, Y., Manson, J. E., & Qi, L. (2022). Red meat consumption and all-cause and cardiovascular mortality: results from the UK Biobank study. European Journal of Nutrition, 61(5), 2543-2553. https://doi.org/10.1007/s00394-022-02807-0
Wang M, et al. Red Meat Consumption and All-cause and Cardiovascular Mortality: Results From the UK Biobank Study. Eur J Nutr. 2022;61(5):2543-2553. PubMed PMID: 35220441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red meat consumption and all-cause and cardiovascular mortality: results from the UK Biobank study. AU - Wang,Mengying, AU - Ma,Hao, AU - Song,Qiying, AU - Zhou,Tao, AU - Hu,Yonghua, AU - Heianza,Yoriko, AU - Manson,JoAnn E, AU - Qi,Lu, Y1 - 2022/02/27/ PY - 2021/08/02/received PY - 2022/01/11/accepted PY - 2022/2/28/pubmed PY - 2022/7/16/medline PY - 2022/2/27/entrez KW - Effect modification KW - Mortality KW - Prospective cohort study KW - Red meat KW - Substitution analysis SP - 2543 EP - 2553 JF - European journal of nutrition JO - Eur J Nutr VL - 61 IS - 5 N2 - PURPOSE: To investigate the prospective associations between red meat consumption and all-cause and cardiovascular diseases (CVD) mortality, and to assess the modification effects of lifestyle and genetic risk factors. METHODS: 180,642 individuals free of CVD or cancer were enrolled from 2006 to 2010 and followed up to 2018 in the UK Biobank. Information on demographics, lifestyles, and medical history was collected through a baseline touchscreen questionnaire. The information on diet was collected through a single touchscreen food-frequency questionnaire. A total of ten single-nucleotide polymorphisms were used to calculate the genetic risk score (GRS) of trimethylamine N-oxide (TMAO), a gut microbiota metabolite from red meat. Adjusted Cox proportional hazard regression models were used to assess the association of red meat consumption with mortality. RESULTS: We documented 3596 deaths [655 CVD deaths, 285 coronary heart disease (CHD) deaths, and 149 stroke deaths] during median 8.6 years of follow-up. Compared with the lowest red meat intake (< 1.5 times/week), the highest red meat intake (≥ 3.0 times/week) was associated with a 20%, 53%, and 101% elevated risk for CVD, CHD, and stroke mortality (P for trend = 0.04, 0.007, and 0.02, respectively), but not all-cause mortality. We found that the associations between red meat intake and mortality were not modified by dietary and lifestyle factors, as well as TMAO GRS. In addition, substitution analyses showed that a decrease in red meat consumption and an increase in the consumption of poultry or cereal was significantly associated with 9%-16% lower CVD or CHD mortality risk. CONCLUSION: Our results indicated that red meat consumption was associated with higher risks of CVD, CHD, and stroke mortality, and the associations were not modified by lifestyle and genetic risk factors. Replacing red meat by poultry or cereal was related to lower risks of CVD and CHD mortality. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/35220441/Red_meat_consumption_and_all_cause_and_cardiovascular_mortality:_results_from_the_UK_Biobank_study_ DB - PRIME DP - Unbound Medicine ER -