Tags

Type your tag names separated by a space and hit enter

Adherence to the Mediterranean diet and the risk of lung cancer: a systematic review and dose-response meta-analysis of observational studies.
Nutr Rev. 2022 04 08; 80(5):1118-1128.NR

Abstract

CONTEXT

The literature supports the protective role of the Mediterranean diet (MD) in the prevention of some types of cancer, such as colorectal and liver cancer. The link between the MD and lung cancer, however, is still unclear.

OBJECTIVE

The aim of this systematic review and meta-analysis was to investigate the association between the MD and risk of lung cancer.

DATA SOURCES

Electronic databases (PubMed, Scopus, Embase, and Web of Science) were searched up to May 2021.

STUDY SELECTION

Case-control and cohort studies reporting the association between intake of the MD and risk of lung cancer and with accessible full texts published in English were included. Review articles, laboratory and animal studies, abstracts, letters to the editor, and studies lacking sufficient data were excluded.

DATA EXTRACTION

The risk ratio (RR) was extracted from eligible studies, and meta-analysis was performed to calculate the pooled RR of the included studies.

RESULTS

Nine studies (8 cohort, 1 case-control) were included in the meta-analysis. High adherence to the MD was associated with a lower likelihood of lung cancer compared with low adherence (RR = 0.84; 95%CI, 0.77-0.91; I2 = 52%, heterogeneity P = 0.03). Dose-response analysis showed that a 2-score increment in MD adherence was associated with a 6% lower risk of lung cancer (RR = 0.94; 95%CI, 0.91-0.96; nonlinearity P = 0.97). Subgroup analyses showed a protective association between MD adherence and risk of lung cancer among former smokers (n = 3 studies) (RR = 0.81; 95%CI, 0.74-0.89), but no significant association was observed for never smokers (n = 3 studies) (RR = 0.78; 95%CI, 0.29-2.07) or current smokers (n = 3 studies) (RR = 0.82; 95%CI, 0.58-1.16). In addition, an inverse association between the MD and lung cancer was observed in both males (RR = 0.84; 95%CI, 0.74-0.96) and females (RR = 0.87; 95%CI, 0.77-0.98).

CONCLUSIONS

High adherence to the MD is associated with a lower risk of lung cancer, especially in former smokers.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO registration no. CRD42019146460.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Bahrami A
Department and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Khalesi S
Physical Activity Research Group, Appleton Institute, School of Health, Medical and Applied Sciences, Central Queensland University, Brisbane, Australia.
Makiabadi E
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alibeyk S
National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hajigholam-Saryazdi M
National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hejazi E
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

MeSH

Case-Control StudiesDiet, MediterraneanFemaleHumansLung NeoplasmsMaleOdds RatioRisk

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35224641

Citation

Bahrami, Alireza, et al. "Adherence to the Mediterranean Diet and the Risk of Lung Cancer: a Systematic Review and Dose-response Meta-analysis of Observational Studies." Nutrition Reviews, vol. 80, no. 5, 2022, pp. 1118-1128.
Bahrami A, Khalesi S, Makiabadi E, et al. Adherence to the Mediterranean diet and the risk of lung cancer: a systematic review and dose-response meta-analysis of observational studies. Nutr Rev. 2022;80(5):1118-1128.
Bahrami, A., Khalesi, S., Makiabadi, E., Alibeyk, S., Hajigholam-Saryazdi, M., & Hejazi, E. (2022). Adherence to the Mediterranean diet and the risk of lung cancer: a systematic review and dose-response meta-analysis of observational studies. Nutrition Reviews, 80(5), 1118-1128. https://doi.org/10.1093/nutrit/nuab117
Bahrami A, et al. Adherence to the Mediterranean Diet and the Risk of Lung Cancer: a Systematic Review and Dose-response Meta-analysis of Observational Studies. Nutr Rev. 2022 04 8;80(5):1118-1128. PubMed PMID: 35224641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to the Mediterranean diet and the risk of lung cancer: a systematic review and dose-response meta-analysis of observational studies. AU - Bahrami,Alireza, AU - Khalesi,Saman, AU - Makiabadi,Elham, AU - Alibeyk,Sepide, AU - Hajigholam-Saryazdi,Maryam, AU - Hejazi,Ehsan, PY - 2022/3/1/pubmed PY - 2022/4/12/medline PY - 2022/2/28/entrez KW - Mediterranean diet KW - dietary pattern KW - dose-response meta-analysis KW - lung cancer SP - 1118 EP - 1128 JF - Nutrition reviews JO - Nutr Rev VL - 80 IS - 5 N2 - CONTEXT: The literature supports the protective role of the Mediterranean diet (MD) in the prevention of some types of cancer, such as colorectal and liver cancer. The link between the MD and lung cancer, however, is still unclear. OBJECTIVE: The aim of this systematic review and meta-analysis was to investigate the association between the MD and risk of lung cancer. DATA SOURCES: Electronic databases (PubMed, Scopus, Embase, and Web of Science) were searched up to May 2021. STUDY SELECTION: Case-control and cohort studies reporting the association between intake of the MD and risk of lung cancer and with accessible full texts published in English were included. Review articles, laboratory and animal studies, abstracts, letters to the editor, and studies lacking sufficient data were excluded. DATA EXTRACTION: The risk ratio (RR) was extracted from eligible studies, and meta-analysis was performed to calculate the pooled RR of the included studies. RESULTS: Nine studies (8 cohort, 1 case-control) were included in the meta-analysis. High adherence to the MD was associated with a lower likelihood of lung cancer compared with low adherence (RR = 0.84; 95%CI, 0.77-0.91; I2 = 52%, heterogeneity P = 0.03). Dose-response analysis showed that a 2-score increment in MD adherence was associated with a 6% lower risk of lung cancer (RR = 0.94; 95%CI, 0.91-0.96; nonlinearity P = 0.97). Subgroup analyses showed a protective association between MD adherence and risk of lung cancer among former smokers (n = 3 studies) (RR = 0.81; 95%CI, 0.74-0.89), but no significant association was observed for never smokers (n = 3 studies) (RR = 0.78; 95%CI, 0.29-2.07) or current smokers (n = 3 studies) (RR = 0.82; 95%CI, 0.58-1.16). In addition, an inverse association between the MD and lung cancer was observed in both males (RR = 0.84; 95%CI, 0.74-0.96) and females (RR = 0.87; 95%CI, 0.77-0.98). CONCLUSIONS: High adherence to the MD is associated with a lower risk of lung cancer, especially in former smokers. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42019146460. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/35224641/Adherence_to_the_Mediterranean_diet_and_the_risk_of_lung_cancer:_a_systematic_review_and_dose_response_meta_analysis_of_observational_studies_ DB - PRIME DP - Unbound Medicine ER -