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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic.
Front Med. 2022 Apr; 16(2):185-195.FM

Abstract

The record speed at which Chinese scientists identified severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and shared its genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19) diagnostics, drugs, and vaccines. It is unprecedented in pandemic control history to develop a dozen successful vaccines in the first year and to immunize over half of the global population in the second year, due to the efforts of the scientific community, biopharmaceutical industry, and regulatory agencies worldwide. The challenges are both great and multidimensional due to the rapid emergence of virus variants and waning of vaccine immunity. Vaccination strategies need to adapt to these challenges to keep population immunity above the herd immunity threshold, by increasing vaccine coverage, especially for older adults and young people, and providing timely booster doses with homologous or heterologous vaccine boosts. Further research should be undertaken to develop more effective vaccines against SARS-CoV-2 variants and to understand the best prime-boost vaccine combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19.

Authors+Show Affiliations

Chinese Center for Disease Control and Prevention, Beijing, 102206, China. yshao@chinaaids.cn. Changping Laboratory, Beijing, 102206, China. yshao@chinaaids.cn.Chinese Center for Disease Control and Prevention, Beijing, 102206, China.Chinese Center for Disease Control and Prevention, Beijing, 102206, China.Department of Infectious Diseases, Research Laboratory of Clinical Virology, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.Department of Policy Science, Central Committee of the Chinese Peasants and Workers Democratic Party, Beijing, 100011, China. xiongfeng@ngd.org.cn.Department of Infectious Diseases, Research Laboratory of Clinical Virology, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zhangx@shsmu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35226300

Citation

Shao, Yiming, et al. "SARS-CoV-2 Vaccine Research and Immunization Strategies for Improved Control of the COVID-19 Pandemic." Frontiers of Medicine, vol. 16, no. 2, 2022, pp. 185-195.
Shao Y, Wu Y, Feng Y, et al. SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic. Front Med. 2022;16(2):185-195.
Shao, Y., Wu, Y., Feng, Y., Xu, W., Xiong, F., & Zhang, X. (2022). SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic. Frontiers of Medicine, 16(2), 185-195. https://doi.org/10.1007/s11684-021-0913-y
Shao Y, et al. SARS-CoV-2 Vaccine Research and Immunization Strategies for Improved Control of the COVID-19 Pandemic. Front Med. 2022;16(2):185-195. PubMed PMID: 35226300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic. AU - Shao,Yiming, AU - Wu,Yingqi, AU - Feng,Yi, AU - Xu,Wenxin, AU - Xiong,Feng, AU - Zhang,Xinxin, Y1 - 2022/02/28/ PY - 2021/11/25/received PY - 2021/12/13/accepted PY - 2022/3/1/pubmed PY - 2022/5/3/medline PY - 2022/2/28/entrez KW - COVID-19 KW - SARS-CoV-2 KW - pandemics KW - vaccination SP - 185 EP - 195 JF - Frontiers of medicine JO - Front Med VL - 16 IS - 2 N2 - The record speed at which Chinese scientists identified severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and shared its genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19) diagnostics, drugs, and vaccines. It is unprecedented in pandemic control history to develop a dozen successful vaccines in the first year and to immunize over half of the global population in the second year, due to the efforts of the scientific community, biopharmaceutical industry, and regulatory agencies worldwide. The challenges are both great and multidimensional due to the rapid emergence of virus variants and waning of vaccine immunity. Vaccination strategies need to adapt to these challenges to keep population immunity above the herd immunity threshold, by increasing vaccine coverage, especially for older adults and young people, and providing timely booster doses with homologous or heterologous vaccine boosts. Further research should be undertaken to develop more effective vaccines against SARS-CoV-2 variants and to understand the best prime-boost vaccine combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19. SN - 2095-0225 UR - https://www.unboundmedicine.com/medline/citation/35226300/SARS_CoV_2_vaccine_research_and_immunization_strategies_for_improved_control_of_the_COVID_19_pandemic_ DB - PRIME DP - Unbound Medicine ER -