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National review of reported Yellow fever vaccine incidents in the UK.
Travel Med Infect Dis. 2022 May-Jun; 47:102289.TM

Abstract

BACKGROUND

Yellow fever (YF) vaccination is the single most important preventative measure against YF infection, however the live attenuated vaccine has associated serious adverse events. All YF vaccinations in England, Wales and Northern Ireland (EWNI) are administered in YF Vaccination Centres and comply with National Travel Health Network and Centre (NaTHNaC) Conditions of Designation and Code of Practice, including reporting of vaccine incidents to NaTHNaC. In this study we evaluated the number and type of YF vaccine incidents in EWNI to identify areas for improvement.

METHODS

NaTHNaC's telephone advice line database was retrospectively searched from 1st January 2016 to 31st December 2018 for YF vaccine incidents. Calls were categorised and analysed according to incident type.

RESULTS

Seventy-eight YF vaccine incidents were reported from a total of 17250 calls. The commonest incident was incorrect timing of measles, mumps and rubella vaccine in relation to YF vaccine, where the recommended 28-day interval was not observed (n = 21). Other incidents included accidental partial vaccination (n = 11), inappropriate vaccination (n = 5) and invalid vaccination due to expiry or cold chain breach (n = 4). Inadvertent vaccination in contraindicated individuals occurred in two travellers with thymectomies (resulting in one death), and five immunocompromised travellers.

CONCLUSIONS

YF vaccine incidents represent a small proportion of total calls. Similar incidents likely occur with other vaccines, but YF vaccine incidents are of particular concern; whilst most incidents were not harmful, vaccination in contraindicated individuals resulted in one death. These findings helped to inform new guidance and update training for staff in YF vaccination centres.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Gnanadurai R
Public Health England, 61 Colindale Avenue, Colindale, London, UK. Electronic address: r.gnanadurai@nhs.net.
Campos-Matos I
Public Health England, 61 Colindale Avenue, Colindale, London, UK; Collaborative Centre for Inclusion Health, University College London Institute of Epidemiology and Health, London, UK.
Kanagarajah S
National Travel Health Network and Centre, 250 Euston Road, London, UK.
Geary K
Public Health England, 61 Colindale Avenue, Colindale, London, UK.
Simons H
National Travel Health Network and Centre, 250 Euston Road, London, UK; Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Patel D
National Travel Health Network and Centre, 250 Euston Road, London, UK.

MeSH

HumansRetrospective StudiesUnited KingdomVaccinationVaccines, AttenuatedYellow FeverYellow Fever Vaccine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35227862

Citation

Gnanadurai, Roshina, et al. "National Review of Reported Yellow Fever Vaccine Incidents in the UK." Travel Medicine and Infectious Disease, vol. 47, 2022, p. 102289.
Gnanadurai R, Campos-Matos I, Kanagarajah S, et al. National review of reported Yellow fever vaccine incidents in the UK. Travel Med Infect Dis. 2022;47:102289.
Gnanadurai, R., Campos-Matos, I., Kanagarajah, S., Geary, K., Simons, H., & Patel, D. (2022). National review of reported Yellow fever vaccine incidents in the UK. Travel Medicine and Infectious Disease, 47, 102289. https://doi.org/10.1016/j.tmaid.2022.102289
Gnanadurai R, et al. National Review of Reported Yellow Fever Vaccine Incidents in the UK. Travel Med Infect Dis. 2022 May-Jun;47:102289. PubMed PMID: 35227862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - National review of reported Yellow fever vaccine incidents in the UK. AU - Gnanadurai,Roshina, AU - Campos-Matos,Ines, AU - Kanagarajah,Sanch, AU - Geary,Katie, AU - Simons,Hilary, AU - Patel,Dipti, Y1 - 2022/02/25/ PY - 2020/06/21/received PY - 2022/01/21/revised PY - 2022/02/23/accepted PY - 2022/3/2/pubmed PY - 2022/5/4/medline PY - 2022/3/1/entrez KW - Serious adverse events KW - Vaccine incidents KW - Yellow fever vaccine SP - 102289 EP - 102289 JF - Travel medicine and infectious disease JO - Travel Med Infect Dis VL - 47 N2 - BACKGROUND: Yellow fever (YF) vaccination is the single most important preventative measure against YF infection, however the live attenuated vaccine has associated serious adverse events. All YF vaccinations in England, Wales and Northern Ireland (EWNI) are administered in YF Vaccination Centres and comply with National Travel Health Network and Centre (NaTHNaC) Conditions of Designation and Code of Practice, including reporting of vaccine incidents to NaTHNaC. In this study we evaluated the number and type of YF vaccine incidents in EWNI to identify areas for improvement. METHODS: NaTHNaC's telephone advice line database was retrospectively searched from 1st January 2016 to 31st December 2018 for YF vaccine incidents. Calls were categorised and analysed according to incident type. RESULTS: Seventy-eight YF vaccine incidents were reported from a total of 17250 calls. The commonest incident was incorrect timing of measles, mumps and rubella vaccine in relation to YF vaccine, where the recommended 28-day interval was not observed (n = 21). Other incidents included accidental partial vaccination (n = 11), inappropriate vaccination (n = 5) and invalid vaccination due to expiry or cold chain breach (n = 4). Inadvertent vaccination in contraindicated individuals occurred in two travellers with thymectomies (resulting in one death), and five immunocompromised travellers. CONCLUSIONS: YF vaccine incidents represent a small proportion of total calls. Similar incidents likely occur with other vaccines, but YF vaccine incidents are of particular concern; whilst most incidents were not harmful, vaccination in contraindicated individuals resulted in one death. These findings helped to inform new guidance and update training for staff in YF vaccination centres. SN - 1873-0442 UR - https://www.unboundmedicine.com/medline/citation/35227862/National_review_of_reported_Yellow_fever_vaccine_incidents_in_the_UK_ DB - PRIME DP - Unbound Medicine ER -