TY - JOUR T1 - Hypoglycemia and counterregulation in insulin-dependent diabetic patients: a comparison of continuous subcutaneous insulin infusion and conventional insulin injection therapy. AU - Ng Tang Fui,S, AU - Pickup,J C, AU - Bending,J J, AU - Collins,A C, AU - Keen,H, AU - Dalton,N, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 221 EP - 7 JF - Diabetes care JO - Diabetes Care VL - 9 IS - 3 N2 - Eleven insulin-dependent diabetic patients were treated in random order by 2-mo continuous subcutaneous insulin infusion (CSII) or 2-mo conventional injection treatment (CIT) with crossover to the alternative regimen. Mean plasma glucose concentrations throughout the day were significantly lower during CSII than during CIT, but the percentage of plasma glucose values less than 2.5 mmol/L, obtained from outpatient self-collected diurnal profiles, was similar for both treatments (CSII vs. CIT: 5.9 and 4.8%, respectively). Reported symptomatic hypoglycemia at home was not significantly different in the whole group of patients treated by CSII or CIT but was reduced by a mean of 57% (P less than .02) in the five patients on CSII who experienced frequent symptomatic hypoglycemic episodes (greater than 4/2 mo) during CIT. Neither the plasma glucose concentration at which the patients recognized induced hypoglycemia nor the glycemic or counterregulatory hormone responses for 60 min thereafter were changed by CSII treatment. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/3525052/Hypoglycemia_and_counterregulation_in_insulin_dependent_diabetic_patients:_a_comparison_of_continuous_subcutaneous_insulin_infusion_and_conventional_insulin_injection_therapy_ DB - PRIME DP - Unbound Medicine ER -