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Impact of progesterone on the gastrointestinal tract: a comprehensive literature review.
Climacteric. 2022 08; 25(4):337-361.C

Abstract

Women are more prone to gastrointestinal symptoms than men. A comprehensive literature search was performed to assess the impact of sex steroid hormone, especially progesterone, on the (healthy and diseased) gastrointestinal tract. Overall, 37 articles were identified. Based on these we conclude that progesterone has a dose-dependent and sex-dependent effect on gastric emptying (especially in mammals), slows down gastrointestinal motility, reduces the gallbladder's response to contractile stimulants, may support gastroesophageal reflux by reducing the esophageal sphincter pressure, may protect from Helicobacter pylori infection gastrointestinal sequelae (especially in mammals) and does not affect inflammatory bowel disease-specific symptoms. However, for several gastrointestinal symptoms and diseases no studies have yet been performed addressing the impact of sex hormone steroids.

Authors+Show Affiliations

Department of Endocrinology and Diabetology, University of Bern, Bern, Switzerland.Department of Surgery, HFR Fribourg - Cantonal Hospital, Fribourg, Switzerland.Department of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35253565

Citation

Coquoz, A, et al. "Impact of Progesterone On the Gastrointestinal Tract: a Comprehensive Literature Review." Climacteric : the Journal of the International Menopause Society, vol. 25, no. 4, 2022, pp. 337-361.
Coquoz A, Regli D, Stute P. Impact of progesterone on the gastrointestinal tract: a comprehensive literature review. Climacteric. 2022;25(4):337-361.
Coquoz, A., Regli, D., & Stute, P. (2022). Impact of progesterone on the gastrointestinal tract: a comprehensive literature review. Climacteric : the Journal of the International Menopause Society, 25(4), 337-361. https://doi.org/10.1080/13697137.2022.2033203
Coquoz A, Regli D, Stute P. Impact of Progesterone On the Gastrointestinal Tract: a Comprehensive Literature Review. Climacteric. 2022;25(4):337-361. PubMed PMID: 35253565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of progesterone on the gastrointestinal tract: a comprehensive literature review. AU - Coquoz,A, AU - Regli,D, AU - Stute,P, Y1 - 2022/03/07/ PY - 2022/3/8/pubmed PY - 2022/7/12/medline PY - 2022/3/7/entrez KW - Micronized progesterone KW - estrogens KW - gallbladder motility KW - gastroesophageal reflux KW - gastrointestinal motility KW - gastrointestinal ulcers KW - inflammatory bowel disease KW - menopause SP - 337 EP - 361 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 25 IS - 4 N2 - Women are more prone to gastrointestinal symptoms than men. A comprehensive literature search was performed to assess the impact of sex steroid hormone, especially progesterone, on the (healthy and diseased) gastrointestinal tract. Overall, 37 articles were identified. Based on these we conclude that progesterone has a dose-dependent and sex-dependent effect on gastric emptying (especially in mammals), slows down gastrointestinal motility, reduces the gallbladder's response to contractile stimulants, may support gastroesophageal reflux by reducing the esophageal sphincter pressure, may protect from Helicobacter pylori infection gastrointestinal sequelae (especially in mammals) and does not affect inflammatory bowel disease-specific symptoms. However, for several gastrointestinal symptoms and diseases no studies have yet been performed addressing the impact of sex hormone steroids. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/35253565/Impact_of_progesterone_on_the_gastrointestinal_tract:_a_comprehensive_literature_review. DB - PRIME DP - Unbound Medicine ER -