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[Selective arterial secretin injection test for localization of gastrinoma].
Nihon Geka Gakkai Zasshi. 1986 Jun; 87(6):671-9.NG

Abstract

We have already shown that gastrinomas release gastrin when stimulated with secretin in vitro. In order to ascertain whether this is true in vivo and whether the reaction is clinically useful in the localization of gastrinomas, secretin was injected into a feeding artery of the gastrinoma in four patients, and blood samples were taken from a peripheral artery (PA) and the hepatic vein (HV) for determination of immunoreactive gastrin (IRG) and immunoreactive insulin (IRI) levels. When secretin was injected into a feeding artery of the gastrinoma, IRG rose within 40 seconds in the HV and within 60 seconds in the PA. When secretin was injected into a nonfeeder, IRG did not rise for 2 min in the PA. This test was performed to two of the postgastrectomized patients and a patient with hypergastrinemia due to atrophic gastritis. In these patients, IRG in the hepatic vein did not rise for two minutes. It was concluded that secretin directly stimulates gastrinomas to release gastrin in vivo and that the selective arterial secretin injection test is helpful in determining the location of the gastrinoma.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

jpn

PubMed ID

3526120

Citation

Imamura, M, et al. "[Selective Arterial Secretin Injection Test for Localization of Gastrinoma]." Nihon Geka Gakkai Zasshi, vol. 87, no. 6, 1986, pp. 671-9.
Imamura M, Minematsu S, Tobe T, et al. [Selective arterial secretin injection test for localization of gastrinoma]. Nihon Geka Gakkai Zasshi. 1986;87(6):671-9.
Imamura, M., Minematsu, S., Tobe, T., Adachi, H., & Takahashi, K. (1986). [Selective arterial secretin injection test for localization of gastrinoma]. Nihon Geka Gakkai Zasshi, 87(6), 671-9.
Imamura M, et al. [Selective Arterial Secretin Injection Test for Localization of Gastrinoma]. Nihon Geka Gakkai Zasshi. 1986;87(6):671-9. PubMed PMID: 3526120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Selective arterial secretin injection test for localization of gastrinoma]. AU - Imamura,M, AU - Minematsu,S, AU - Tobe,T, AU - Adachi,H, AU - Takahashi,K, PY - 1986/6/1/pubmed PY - 1986/6/1/medline PY - 1986/6/1/entrez SP - 671 EP - 9 JF - Nihon Geka Gakkai zasshi JO - Nihon Geka Gakkai Zasshi VL - 87 IS - 6 N2 - We have already shown that gastrinomas release gastrin when stimulated with secretin in vitro. In order to ascertain whether this is true in vivo and whether the reaction is clinically useful in the localization of gastrinomas, secretin was injected into a feeding artery of the gastrinoma in four patients, and blood samples were taken from a peripheral artery (PA) and the hepatic vein (HV) for determination of immunoreactive gastrin (IRG) and immunoreactive insulin (IRI) levels. When secretin was injected into a feeding artery of the gastrinoma, IRG rose within 40 seconds in the HV and within 60 seconds in the PA. When secretin was injected into a nonfeeder, IRG did not rise for 2 min in the PA. This test was performed to two of the postgastrectomized patients and a patient with hypergastrinemia due to atrophic gastritis. In these patients, IRG in the hepatic vein did not rise for two minutes. It was concluded that secretin directly stimulates gastrinomas to release gastrin in vivo and that the selective arterial secretin injection test is helpful in determining the location of the gastrinoma. SN - 0301-4894 UR - https://www.unboundmedicine.com/medline/citation/3526120/[Selective_arterial_secretin_injection_test_for_localization_of_gastrinoma]_ DB - PRIME DP - Unbound Medicine ER -