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Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls.
N Engl J Med. 1986 Aug 21; 315(8):480-4.NEJM

Abstract

Leukotrienes C4 and D4 may serve as chemical mediators in asthma. Although patients with asthma are known to be hyperresponsive to the bronchoconstrictive effects of histamine and methacholine, whether the same is true for the leukotrienes is controversial. We compared the airway responses to methacholine and to leukotrienes C4 and D4 in 12 asthmatic patients and 6 controls. We found that the patients were more responsive to the leukotrienes than the controls, and we observed a linear correlation between airway response to methacholine and that to leukotriene C4 (r = 0.68, P less than 0.01) and D4 (r = 0.79, P less than 0.001). However, relative to the airway response to methacholine, the response to the leukotrienes was much greater in the controls than in the patients. Furthermore, the asthmatic subjects who were most responsive to methacholine had the lowest relative airway response to both leukotrienes. Thus, the patients with the greatest airway responsiveness to methacholine paradoxically showed the lowest relative airway response to the leukotrienes. In contrast, this difference in relative airway responses has not been observed between methacholine and other bronchoconstrictor mediators, such as histamine. Although no adequate explanation for these observations has yet emerged, our data suggest that leukotrienes C4 and D4 are unique bronchoconstrictors with a possible role in the pathogenesis of asthma.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3526153

Citation

Adelroth, E, et al. "Airway Responsiveness to Leukotrienes C4 and D4 and to Methacholine in Patients With Asthma and Normal Controls." The New England Journal of Medicine, vol. 315, no. 8, 1986, pp. 480-4.
Adelroth E, Morris MM, Hargreave FE, et al. Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. N Engl J Med. 1986;315(8):480-4.
Adelroth, E., Morris, M. M., Hargreave, F. E., & O'Byrne, P. M. (1986). Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. The New England Journal of Medicine, 315(8), 480-4.
Adelroth E, et al. Airway Responsiveness to Leukotrienes C4 and D4 and to Methacholine in Patients With Asthma and Normal Controls. N Engl J Med. 1986 Aug 21;315(8):480-4. PubMed PMID: 3526153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. AU - Adelroth,E, AU - Morris,M M, AU - Hargreave,F E, AU - O'Byrne,P M, PY - 1986/8/21/pubmed PY - 1986/8/21/medline PY - 1986/8/21/entrez SP - 480 EP - 4 JF - The New England journal of medicine JO - N Engl J Med VL - 315 IS - 8 N2 - Leukotrienes C4 and D4 may serve as chemical mediators in asthma. Although patients with asthma are known to be hyperresponsive to the bronchoconstrictive effects of histamine and methacholine, whether the same is true for the leukotrienes is controversial. We compared the airway responses to methacholine and to leukotrienes C4 and D4 in 12 asthmatic patients and 6 controls. We found that the patients were more responsive to the leukotrienes than the controls, and we observed a linear correlation between airway response to methacholine and that to leukotriene C4 (r = 0.68, P less than 0.01) and D4 (r = 0.79, P less than 0.001). However, relative to the airway response to methacholine, the response to the leukotrienes was much greater in the controls than in the patients. Furthermore, the asthmatic subjects who were most responsive to methacholine had the lowest relative airway response to both leukotrienes. Thus, the patients with the greatest airway responsiveness to methacholine paradoxically showed the lowest relative airway response to the leukotrienes. In contrast, this difference in relative airway responses has not been observed between methacholine and other bronchoconstrictor mediators, such as histamine. Although no adequate explanation for these observations has yet emerged, our data suggest that leukotrienes C4 and D4 are unique bronchoconstrictors with a possible role in the pathogenesis of asthma. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/3526153/Airway_responsiveness_to_leukotrienes_C4_and_D4_and_to_methacholine_in_patients_with_asthma_and_normal_controls_ L2 - https://www.nejm.org/doi/10.1056/NEJM198608213150803?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -