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Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study.
Nutrients. 2022 Mar 05; 14(5)N

Abstract

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999-1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865-1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940-1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development.

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Authors+Show Affiliations

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China. Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China.

Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China. School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271000, China. The Second Affiliated Hospital of Shandong First Medical University, Tai'an 271000, China.

MeSH

AdipokinesGenome-Wide Association StudyGoutHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35268067

Citation

Cong, Ruyi, et al. "Assessing the Causal Effects of Adipokines On Uric Acid and Gout: a Two-Sample Mendelian Randomization Study." Nutrients, vol. 14, no. 5, 2022.

Cong R, Zhang X, Song Z, et al. Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study. Nutrients. 2022;14(5).

Cong, R., Zhang, X., Song, Z., Chen, S., Liu, G., Liu, Y., Pang, X., Dong, F., Xing, W., Wang, Y., & Xu, X. (2022). Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study. Nutrients, 14(5). https://doi.org/10.3390/nu14051091

Cong R, et al. Assessing the Causal Effects of Adipokines On Uric Acid and Gout: a Two-Sample Mendelian Randomization Study. Nutrients. 2022 Mar 5;14(5) PubMed PMID: 35268067.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study. AU - Cong,Ruyi, AU - Zhang,Xiaoyu, AU - Song,Zihong, AU - Chen,Shanshan, AU - Liu,Guanhua, AU - Liu,Yizhi, AU - Pang,Xiuyu, AU - Dong,Fang, AU - Xing,Weijia, AU - Wang,Youxin, AU - Xu,Xizhu, Y1 - 2022/03/05/ PY - 2022/01/30/received PY - 2022/02/26/revised PY - 2022/03/03/accepted PY - 2022/3/10/entrez PY - 2022/3/11/pubmed PY - 2022/3/15/medline KW - adiponectin KW - gout KW - mendelian randomization KW - soluble leptin receptors KW - uric acid JF - Nutrients JO - Nutrients VL - 14 IS - 5 N2 - Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999-1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865-1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940-1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/35268067/Assessing_the_Causal_Effects_of_Adipokines_on_Uric_Acid_and_Gout:_A_Two_Sample_Mendelian_Randomization_Study_ DB - PRIME DP - Unbound Medicine ER -