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Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain.
Clin Exp Immunol. 1986 May; 64(2):261-8.CE

Abstract

Class II antigens of the major histocompatibility complex (MHC) are normally expressed only by cells of the immune system. They may, however, also appear on other cells, both in vivo and in vitro. We have studied class II MHC antigen expression on human arterial smooth muscle cells using immunocytochemical analysis of surgical biopsies. The class II antigens, HLA-DQ and HLA-DR are virtually absent from cells of normal arteries, but appear in atherosclerotically transformed tissue, where the majority of cells express HLA-DR, and one-third of the cells express HLA-DQ. These atherosclerotic plaques are composed of a heterogeneous population of cells, which includes smooth muscle cells, macrophages, and T cells. Among smooth muscle cells containing the muscle-specific intermediate filament protein desmin, one-third of the cells express HLA-DR and almost as many express HLA-DQ. These cells also contain the invariant gamma chain, which is associated with class II antigens during intracellular transport. Plaque macrophages, in contrast, are usually of the DQ-DR+ phenotype. The patterns of class II antigen expression are discussed in relation to cell differentiation and pathogenesis of disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3527502

Citation

Hansson, G K., et al. "Class II MHC Antigen Expression in the Atherosclerotic Plaque: Smooth Muscle Cells Express HLA-DR, HLA-DQ and the Invariant Gamma Chain." Clinical and Experimental Immunology, vol. 64, no. 2, 1986, pp. 261-8.
Hansson GK, Jonasson L, Holm J, et al. Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. Clin Exp Immunol. 1986;64(2):261-8.
Hansson, G. K., Jonasson, L., Holm, J., & Claesson-Welsh, L. (1986). Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. Clinical and Experimental Immunology, 64(2), 261-8.
Hansson GK, et al. Class II MHC Antigen Expression in the Atherosclerotic Plaque: Smooth Muscle Cells Express HLA-DR, HLA-DQ and the Invariant Gamma Chain. Clin Exp Immunol. 1986;64(2):261-8. PubMed PMID: 3527502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. AU - Hansson,G K, AU - Jonasson,L, AU - Holm,J, AU - Claesson-Welsh,L, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 261 EP - 8 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 64 IS - 2 N2 - Class II antigens of the major histocompatibility complex (MHC) are normally expressed only by cells of the immune system. They may, however, also appear on other cells, both in vivo and in vitro. We have studied class II MHC antigen expression on human arterial smooth muscle cells using immunocytochemical analysis of surgical biopsies. The class II antigens, HLA-DQ and HLA-DR are virtually absent from cells of normal arteries, but appear in atherosclerotically transformed tissue, where the majority of cells express HLA-DR, and one-third of the cells express HLA-DQ. These atherosclerotic plaques are composed of a heterogeneous population of cells, which includes smooth muscle cells, macrophages, and T cells. Among smooth muscle cells containing the muscle-specific intermediate filament protein desmin, one-third of the cells express HLA-DR and almost as many express HLA-DQ. These cells also contain the invariant gamma chain, which is associated with class II antigens during intracellular transport. Plaque macrophages, in contrast, are usually of the DQ-DR+ phenotype. The patterns of class II antigen expression are discussed in relation to cell differentiation and pathogenesis of disease. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/3527502/Class_II_MHC_antigen_expression_in_the_atherosclerotic_plaque:_smooth_muscle_cells_express_HLA_DR_HLA_DQ_and_the_invariant_gamma_chain_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3527502/ DB - PRIME DP - Unbound Medicine ER -