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Cryptococcosis involving the eye and central nervous system of a dog.
J Am Vet Med Assoc. 1986 Aug 01; 189(3):302-4.JA

Abstract

Cryptococcus neoformans meningoencephalitis was diagnosed as the cause of stupor and generalized seizures in a 2-year-old Cocker Spaniel. Unilateral granulomatous chorioretinitis was observed ophthalmoscopically, and isolation of C neoformans from CSF confirmed the antemortem diagnosis. The dog was euthanatized and necropsied. Multifocal lesions were seen throughout the lungs, nasal turbinates, cerebral cortex, and the optic nerve of each eye. Microscopically, the multifocal lesions were granulomas consisting of lymphocytes, macrophages, plasma cells, and cryptococcal organisms. Infection may have originated in the nasal passages and extended directly through the ethmoid plate into the meninges of the CNS and optic nerves. Although the prognosis is poor in dogs with CNS involvement, various chemotherapeutic agents are available for use by clinicians.

Authors

Jergens AE
No affiliation info available
Wheeler CA
No affiliation info available
Collier LL
No affiliation info available

MeSH

AnimalsCentral Nervous System DiseasesCryptococcosisCryptococcus neoformansDog DiseasesDogsEye DiseasesFemale

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3528100

Citation

Jergens, A E., et al. "Cryptococcosis Involving the Eye and Central Nervous System of a Dog." Journal of the American Veterinary Medical Association, vol. 189, no. 3, 1986, pp. 302-4.
Jergens AE, Wheeler CA, Collier LL. Cryptococcosis involving the eye and central nervous system of a dog. J Am Vet Med Assoc. 1986;189(3):302-4.
Jergens, A. E., Wheeler, C. A., & Collier, L. L. (1986). Cryptococcosis involving the eye and central nervous system of a dog. Journal of the American Veterinary Medical Association, 189(3), 302-4.
Jergens AE, Wheeler CA, Collier LL. Cryptococcosis Involving the Eye and Central Nervous System of a Dog. J Am Vet Med Assoc. 1986 Aug 1;189(3):302-4. PubMed PMID: 3528100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryptococcosis involving the eye and central nervous system of a dog. AU - Jergens,A E, AU - Wheeler,C A, AU - Collier,L L, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 302 EP - 4 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 189 IS - 3 N2 - Cryptococcus neoformans meningoencephalitis was diagnosed as the cause of stupor and generalized seizures in a 2-year-old Cocker Spaniel. Unilateral granulomatous chorioretinitis was observed ophthalmoscopically, and isolation of C neoformans from CSF confirmed the antemortem diagnosis. The dog was euthanatized and necropsied. Multifocal lesions were seen throughout the lungs, nasal turbinates, cerebral cortex, and the optic nerve of each eye. Microscopically, the multifocal lesions were granulomas consisting of lymphocytes, macrophages, plasma cells, and cryptococcal organisms. Infection may have originated in the nasal passages and extended directly through the ethmoid plate into the meninges of the CNS and optic nerves. Although the prognosis is poor in dogs with CNS involvement, various chemotherapeutic agents are available for use by clinicians. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/3528100/Cryptococcosis_involving_the_eye_and_central_nervous_system_of_a_dog_ DB - PRIME DP - Unbound Medicine ER -