TY - JOUR T1 - Delta-9-Tetrahydrocannabinolic Acid B: A Mechanism for its Formation in Cannabis. A1 - Filer,Crist N, Y1 - 2022/03/15/ PY - 2022/3/16/pubmed PY - 2023/2/10/medline PY - 2022/3/15/entrez KW - Cannabis KW - THCA-B KW - photochemistry KW - tetrahydrocannabinolic acid B SP - 1 EP - 4 JF - Cannabis and cannabinoid research JO - Cannabis Cannabinoid Res VL - 8 IS - 1 N2 - There appears to be consensus among Cannabis biologists that delta-9-tetrahydrocannabinolic acid A (THCA-A) is the exclusive product of the enzyme THCA synthase. This then leaves an open question for formation of the THCA-A structural isomer, delta-9-tetrahydrocannabinolic acid B (THCA-B), discovered as a minor product in Cannabis in 1969. With no reasonable biochemical pathway to explain the presence of THCA-B in Cannabis, a synthetic route was next considered. Using established literature precedent, a photochemical mechanism has been proposed for the conversion of THCA-A to cannabidiolic acid (CBDA), followed by conversion of CBDA to THCA-B employing bond-breaking and bond-forming reactions. SN - 2378-8763 UR - https://www.unboundmedicine.com/medline/citation/35290744/Delta_9_Tetrahydrocannabinolic_Acid_B:_A_Mechanism_for_its_Formation_in_Cannabis_ DB - PRIME DP - Unbound Medicine ER -