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Effect of soy isoflavones on C-reactive protein in chronic inflammatory disorders.
Int J Vitam Nutr Res. 2022 Apr 16 [Online ahead of print]IJ

Abstract

New evidence suggests that soy products might reduce chronic systemic inflammation. Therefore, we aimed to summarize the effect of soy isoflavones on serum concentration of C-reactive protein (CRP) among participants with chronic inflammatory disorders by conducting this study. Cochrane Library, Scopus, ISI Web of Science, clinicaltrials.gov, and PubMed were searched to identify randomized clinical trials (RCTs) published up to December 2020. The effect size was calculated by the mean change from baseline in concentrations of CRP and its standard deviation for both intervention and comparison groups. DerSimonian and Laird random-effects model was used when the heterogeneity test was statistically significant. In total, thirteen RCTs involving 1213 participants and ten RCTs involving 1052 participants were eligible for our systematic review and meta-analysis respectively. Study duration ranged from 4 to 96 weeks and soy isoflavones dose varied from 33 to 132 mg/day. Overall effect size indicated a non-significant effect on serum concentration of CRP following soy isoflavones intake (weighted mean differences (WMD)=-0.15 mg/L, 95% confidence interval (CI): -0.54, 0.23; p=0.430). Subgroup analysis revealed that soy isoflavones significantly reduced serum concentration of CRP in studies among participants with age >57 years and baseline CRP levels >3.75 mg/L. The present study proposed that soy isoflavones could not significantly reduce serum CRP levels. It seems more RCTs on participants with age more than 57 years and higher levels of CRP is necessary.

Authors+Show Affiliations

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35291882

Citation

Gholami, Ali, et al. "Effect of Soy Isoflavones On C-reactive Protein in Chronic Inflammatory Disorders." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 2022.
Gholami A, Darudi F, Baradaran HR, et al. Effect of soy isoflavones on C-reactive protein in chronic inflammatory disorders. Int J Vitam Nutr Res. 2022.
Gholami, A., Darudi, F., Baradaran, H. R., & Hariri, M. (2022). Effect of soy isoflavones on C-reactive protein in chronic inflammatory disorders. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition. https://doi.org/10.1024/0300-9831/a000751
Gholami A, et al. Effect of Soy Isoflavones On C-reactive Protein in Chronic Inflammatory Disorders. Int J Vitam Nutr Res. 2022 Apr 16; PubMed PMID: 35291882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of soy isoflavones on C-reactive protein in chronic inflammatory disorders. AU - Gholami,Ali, AU - Darudi,Fatemeh, AU - Baradaran,Hamid Reza, AU - Hariri,Mitra, Y1 - 2022/04/16/ PY - 2022/3/16/entrez PY - 2022/3/17/pubmed PY - 2022/3/17/medline KW - C-reactive protein KW - Soy isoflavones KW - meta-analysis KW - systematic review JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res N2 - New evidence suggests that soy products might reduce chronic systemic inflammation. Therefore, we aimed to summarize the effect of soy isoflavones on serum concentration of C-reactive protein (CRP) among participants with chronic inflammatory disorders by conducting this study. Cochrane Library, Scopus, ISI Web of Science, clinicaltrials.gov, and PubMed were searched to identify randomized clinical trials (RCTs) published up to December 2020. The effect size was calculated by the mean change from baseline in concentrations of CRP and its standard deviation for both intervention and comparison groups. DerSimonian and Laird random-effects model was used when the heterogeneity test was statistically significant. In total, thirteen RCTs involving 1213 participants and ten RCTs involving 1052 participants were eligible for our systematic review and meta-analysis respectively. Study duration ranged from 4 to 96 weeks and soy isoflavones dose varied from 33 to 132 mg/day. Overall effect size indicated a non-significant effect on serum concentration of CRP following soy isoflavones intake (weighted mean differences (WMD)=-0.15 mg/L, 95% confidence interval (CI): -0.54, 0.23; p=0.430). Subgroup analysis revealed that soy isoflavones significantly reduced serum concentration of CRP in studies among participants with age >57 years and baseline CRP levels >3.75 mg/L. The present study proposed that soy isoflavones could not significantly reduce serum CRP levels. It seems more RCTs on participants with age more than 57 years and higher levels of CRP is necessary. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/35291882/Effect_of_soy_isoflavones_on_C_reactive_protein_in_chronic_inflammatory_disorders_ DB - PRIME DP - Unbound Medicine ER -
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