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Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo.
Nat Commun. 2022 03 18; 13(1):1448.NC

Abstract

Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission by 2030. While annual new cases are at a historical minimum, the likelihood of achieving the target is unknown. We utilised modelling to study the impacts of four strategies using currently available interventions, including active and passive screening and vector control, on disease burden and transmission across 168 endemic health zones in the Democratic Republic of the Congo. Median projected years of elimination of transmission show only 98 health zones are on track despite significant reduction in disease burden under medical-only strategies (64 health zones if > 90% certainty required). Blanket coverage with vector control is impractical, but is predicted to reach the target in all heath zones. Utilising projected disease burden under the uniform medical-only strategy, we provide a priority list of health zones for consideration for supplementary vector control alongside medical interventions.

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Authors+Show Affiliations

Huang CI
Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick, Coventry, UK. ching-i.huang@warwick.ac.uk. Mathematics Institute, The University of Warwick, Coventry, UK. ching-i.huang@warwick.ac.uk.
Crump RE
Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick, Coventry, UK. Mathematics Institute, The University of Warwick, Coventry, UK. The School of Life Sciences, The University of Warwick, Coventry, UK.
Brown PE
Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick, Coventry, UK. Mathematics Institute, The University of Warwick, Coventry, UK.
Spencer SEF
Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick, Coventry, UK. The Department of Statistics, The University of Warwick, Coventry, UK.
Miaka EM
Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Kinshasa, Democratic Republic of the Congo.
Shampa C
Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Kinshasa, Democratic Republic of the Congo.
Keeling MJ
Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick, Coventry, UK. Mathematics Institute, The University of Warwick, Coventry, UK. The School of Life Sciences, The University of Warwick, Coventry, UK.
Rock KS
Zeeman Institute for System Biology and Infectious Disease Epidemiology Research, The University of Warwick, Coventry, UK. Mathematics Institute, The University of Warwick, Coventry, UK.

MeSH

Democratic Republic of the CongoHumansMass ScreeningProbabilityTrypanosoma brucei gambienseTrypanosomiasis, African

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35304479

Citation

Huang, Ching-I, et al. "Identifying Regions for Enhanced Control of Gambiense Sleeping Sickness in the Democratic Republic of Congo." Nature Communications, vol. 13, no. 1, 2022, p. 1448.
Huang CI, Crump RE, Brown PE, et al. Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo. Nat Commun. 2022;13(1):1448.
Huang, C. I., Crump, R. E., Brown, P. E., Spencer, S. E. F., Miaka, E. M., Shampa, C., Keeling, M. J., & Rock, K. S. (2022). Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo. Nature Communications, 13(1), 1448. https://doi.org/10.1038/s41467-022-29192-w
Huang CI, et al. Identifying Regions for Enhanced Control of Gambiense Sleeping Sickness in the Democratic Republic of Congo. Nat Commun. 2022 03 18;13(1):1448. PubMed PMID: 35304479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo. AU - Huang,Ching-I, AU - Crump,Ronald E, AU - Brown,Paul E, AU - Spencer,Simon E F, AU - Miaka,Erick Mwamba, AU - Shampa,Chansy, AU - Keeling,Matt J, AU - Rock,Kat S, Y1 - 2022/03/18/ PY - 2021/04/12/received PY - 2022/02/28/accepted PY - 2022/3/19/entrez PY - 2022/3/20/pubmed PY - 2022/4/6/medline SP - 1448 EP - 1448 JF - Nature communications JO - Nat Commun VL - 13 IS - 1 N2 - Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission by 2030. While annual new cases are at a historical minimum, the likelihood of achieving the target is unknown. We utilised modelling to study the impacts of four strategies using currently available interventions, including active and passive screening and vector control, on disease burden and transmission across 168 endemic health zones in the Democratic Republic of the Congo. Median projected years of elimination of transmission show only 98 health zones are on track despite significant reduction in disease burden under medical-only strategies (64 health zones if > 90% certainty required). Blanket coverage with vector control is impractical, but is predicted to reach the target in all heath zones. Utilising projected disease burden under the uniform medical-only strategy, we provide a priority list of health zones for consideration for supplementary vector control alongside medical interventions. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/35304479/Identifying_regions_for_enhanced_control_of_gambiense_sleeping_sickness_in_the_Democratic_Republic_of_Congo_ DB - PRIME DP - Unbound Medicine ER -