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The Impact of COVID-19 and Vaccine on the Human Nervous System.
Neuroendocrinology. 2022; 112(11):1046-1057.N

Abstract

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Due to its severe impact, multiple COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious adverse events (AEs) were reported after the application of them, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Particularly, previous vaccination campaigns have shown us that partial vaccination can induce neurologic AEs. Herein, we discuss in depth the involvement of the nervous system during SARS-CoV-2 infection or after vaccination. On the one hand, COVID-19 could pose an enormous threat to human neurological health through direct infection and indirect neurotoxicity effects. On the other hand, our review indicated that only a few serious neurological AEs following vaccination occurred and among which headache was the most common. Moreover, some neurological AEs do not seem to be related to vaccination. Of course, the causal relationships between several vaccines and AEs are considered plausible, and it is not doubtful that these AEs should be taken seriously by clinicians in assessing the potential risks and benefits of vaccinations in special populations. Nevertheless, in the case of the rapid spread of COVID-19, the potential side effects of vaccination on the nervous system should be compared with adverse COVID-19 outcomes rather than being considered alone. Thus, it is obviously a wise option to be vaccinated instead of suffering from serious adverse symptoms of virus infection.

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Authors+Show Affiliations

Chen F
Department of Physiology, Jining Medical University, Jining, China.
Cao P
Department of Physiology, Jining Medical University, Jining, China.
Liu H
Department of Physiology, Jining Medical University, Jining, China.
Cai D
Department of Physiology, Jining Medical University, Jining, China.

MeSH

HumansInfluenza VaccinesCOVID-19Diphtheria-Tetanus-Pertussis VaccineCOVID-19 VaccinesAIDS VaccinesBCG VaccineDiphtheria-Tetanus VaccineMeasles-Mumps-Rubella VaccineRespiratory Syncytial Virus VaccinesSAIDS VaccinesSARS-CoV-2Nervous SystemPapillomavirus Vaccines

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35316815

Citation

Chen, Fei, et al. "The Impact of COVID-19 and Vaccine On the Human Nervous System." Neuroendocrinology, vol. 112, no. 11, 2022, pp. 1046-1057.
Chen F, Cao P, Liu H, et al. The Impact of COVID-19 and Vaccine on the Human Nervous System. Neuroendocrinology. 2022;112(11):1046-1057.
Chen, F., Cao, P., Liu, H., & Cai, D. (2022). The Impact of COVID-19 and Vaccine on the Human Nervous System. Neuroendocrinology, 112(11), 1046-1057. https://doi.org/10.1159/000524234
Chen F, et al. The Impact of COVID-19 and Vaccine On the Human Nervous System. Neuroendocrinology. 2022;112(11):1046-1057. PubMed PMID: 35316815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Impact of COVID-19 and Vaccine on the Human Nervous System. AU - Chen,Fei, AU - Cao,Pingdong, AU - Liu,Huimin, AU - Cai,Dechen, Y1 - 2022/03/22/ PY - 2021/10/17/received PY - 2022/03/07/accepted PY - 2022/3/23/pubmed PY - 2022/10/26/medline PY - 2022/3/22/entrez KW - AZD1222 KW - Bell’s palsy KW - COVID-19 vaccines KW - Guillain-Barré syndrome KW - Neurological adverse events KW - Severe acute respiratory syndrome coronavirus 2 KW - mRNA vaccine SP - 1046 EP - 1057 JF - Neuroendocrinology JO - Neuroendocrinology VL - 112 IS - 11 N2 - The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Due to its severe impact, multiple COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious adverse events (AEs) were reported after the application of them, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Particularly, previous vaccination campaigns have shown us that partial vaccination can induce neurologic AEs. Herein, we discuss in depth the involvement of the nervous system during SARS-CoV-2 infection or after vaccination. On the one hand, COVID-19 could pose an enormous threat to human neurological health through direct infection and indirect neurotoxicity effects. On the other hand, our review indicated that only a few serious neurological AEs following vaccination occurred and among which headache was the most common. Moreover, some neurological AEs do not seem to be related to vaccination. Of course, the causal relationships between several vaccines and AEs are considered plausible, and it is not doubtful that these AEs should be taken seriously by clinicians in assessing the potential risks and benefits of vaccinations in special populations. Nevertheless, in the case of the rapid spread of COVID-19, the potential side effects of vaccination on the nervous system should be compared with adverse COVID-19 outcomes rather than being considered alone. Thus, it is obviously a wise option to be vaccinated instead of suffering from serious adverse symptoms of virus infection. SN - 1423-0194 UR - https://www.unboundmedicine.com/medline/citation/35316815/The_Impact_of_COVID_19_and_Vaccine_on_the_Human_Nervous_System_ DB - PRIME DP - Unbound Medicine ER -