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Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis.
Auris Nasus Larynx. 2022 Oct; 49(5):748-754.AN

Abstract

OBJECTIVE

To examine the evidence for treating children with otitis media with effusion with pharmacotherapy.

DATA SOURCES

For the systematic review, data were retrieved from PubMed, Cochrane database, and the Japan Medical Abstracts Society Database (1st January 1995 through 31th May 2019).

STUDY SELECTION

Articles addressing pharmacotherapy for the management of otitis media with effusion in children were selected in English.

DATA EXTRACTION

The database was searched using the keywords "Otitis Media with effusion or secretory otitis media" and the following medical agents: carbocysteine, antihistamines, leukotriene receptor antagonist, and steroid nasal spray.

DATA SYNTHESIS

After a critical review of 18 studies, studies addressing steroid nasal spray were eligible for quantitative synthesis. Intranasal steroids for OME showed no benefit with OR 1.155 (95% CI 0.834-1.598) within one month. Conversely, intranasal steroids have effects for OME with OR 1.858 (95% CI 1.240-2.786) for more than one month.

CONCLUSIONS

We found evidence of benefit from treatment of OME in children with intranasal steroids and S-carboxymethylcysteine at longer-term follow-up.

Authors+Show Affiliations

Department of Otorhinolaryngology-Head and Neck Surgery, Tohoku University School of Medicine. Electronic address: ryoukich@hotmail.com.Department of Otorhinolaryngology, Head and Neck Surgery, Kansai Medcal University.Department of Pediatric Otolaryngology, Jichi Children's Medical Center Tochigi, Jichi Medical University.Kamide Ear Nose and Throat Clinic.Sotobo Children's Clinic.Division of Otorhinolaryngology, Chiba Children's Hospital.Department of Otolaryngology, Nagasaki Harbor Medical Center.Department of Otolaryngology, Nagasaki Harbor Medical Center.Department of Otolaryngology, Tokyo-Kita Medical Center.Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University.Department of Otorhinolaryngology, Showa University School of Medicine.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

35341623

Citation

Ikeda, Ryoukichi, et al. "Pharmacotherapy Focusing On for the Management of Otitis Media With Effusion in Children: Systematic Review and Meta-analysis." Auris, Nasus, Larynx, vol. 49, no. 5, 2022, pp. 748-754.
Ikeda R, Hidaka H, Ito M, et al. Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis. Auris Nasus Larynx. 2022;49(5):748-754.
Ikeda, R., Hidaka, H., Ito, M., Kamide, Y., Kuroki, H., Nakano, A., Yoshida, H., Takahashi, H., Iino, Y., Harabuchi, Y., & Kobayashi, H. (2022). Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis. Auris, Nasus, Larynx, 49(5), 748-754. https://doi.org/10.1016/j.anl.2022.03.017
Ikeda R, et al. Pharmacotherapy Focusing On for the Management of Otitis Media With Effusion in Children: Systematic Review and Meta-analysis. Auris Nasus Larynx. 2022;49(5):748-754. PubMed PMID: 35341623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis. AU - Ikeda,Ryoukichi, AU - Hidaka,Hiroshi, AU - Ito,Makoto, AU - Kamide,Yosuke, AU - Kuroki,Haruo, AU - Nakano,Atsuko, AU - Yoshida,Haruo, AU - Takahashi,Haruo, AU - Iino,Yukiko, AU - Harabuchi,Yasuaki, AU - Kobayashi,Hitome, Y1 - 2022/03/24/ PY - 2021/11/02/received PY - 2022/01/15/revised PY - 2022/03/13/accepted PY - 2022/3/29/pubmed PY - 2022/3/29/medline PY - 2022/3/28/entrez KW - Antihistamines, leukotriene receptor antagonist KW - Carbocysteine KW - Meta-analysis KW - Otitis media with effusion KW - Steroid nasal spray KW - Systematic review SP - 748 EP - 754 JF - Auris, nasus, larynx JO - Auris Nasus Larynx VL - 49 IS - 5 N2 - OBJECTIVE: To examine the evidence for treating children with otitis media with effusion with pharmacotherapy. DATA SOURCES: For the systematic review, data were retrieved from PubMed, Cochrane database, and the Japan Medical Abstracts Society Database (1st January 1995 through 31th May 2019). STUDY SELECTION: Articles addressing pharmacotherapy for the management of otitis media with effusion in children were selected in English. DATA EXTRACTION: The database was searched using the keywords "Otitis Media with effusion or secretory otitis media" and the following medical agents: carbocysteine, antihistamines, leukotriene receptor antagonist, and steroid nasal spray. DATA SYNTHESIS: After a critical review of 18 studies, studies addressing steroid nasal spray were eligible for quantitative synthesis. Intranasal steroids for OME showed no benefit with OR 1.155 (95% CI 0.834-1.598) within one month. Conversely, intranasal steroids have effects for OME with OR 1.858 (95% CI 1.240-2.786) for more than one month. CONCLUSIONS: We found evidence of benefit from treatment of OME in children with intranasal steroids and S-carboxymethylcysteine at longer-term follow-up. SN - 1879-1476 UR - https://www.unboundmedicine.com/medline/citation/35341623/Pharmacotherapy_focusing_on_for_the_management_of_otitis_media_with_effusion_in_children:_Systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0385-8146(22)00072-4 DB - PRIME DP - Unbound Medicine ER -