Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis.Auris Nasus Larynx. 2022 Oct; 49(5):748-754.AN
To examine the evidence for treating children with otitis media with effusion with pharmacotherapy.
For the systematic review, data were retrieved from PubMed, Cochrane database, and the Japan Medical Abstracts Society Database (1st January 1995 through 31th May 2019).
Articles addressing pharmacotherapy for the management of otitis media with effusion in children were selected in English.
The database was searched using the keywords "Otitis Media with effusion or secretory otitis media" and the following medical agents: carbocysteine, antihistamines, leukotriene receptor antagonist, and steroid nasal spray.
After a critical review of 18 studies, studies addressing steroid nasal spray were eligible for quantitative synthesis. Intranasal steroids for OME showed no benefit with OR 1.155 (95% CI 0.834-1.598) within one month. Conversely, intranasal steroids have effects for OME with OR 1.858 (95% CI 1.240-2.786) for more than one month.
We found evidence of benefit from treatment of OME in children with intranasal steroids and S-carboxymethylcysteine at longer-term follow-up.